Synthesis and Biological Activity of Some New Pyrazole Copper(II) Complexes

Abstract

As a part of systematic investigation of synthesis and biologically active compounds of pyrazole derivatives containing transition metal, several new pyrazole copper(II) complexes 3a−f were synthesized from pyrazole sodium salts 2a−f, which were produced from spiro‐pyrazoles 1a−f and sodium hydride by a ring‐opening reaction. All the synthesized compounds were characterized by spectroscopic analysis. Pyrazole copper(II) complexes 3a−d and 3f exhibited high DNA cleavage activity in vitro. Furthermore, compounds 3a−f were tested for their growth inhibitory activity in A549 lung cancer, B16F10 murine melanoma, and HeLa human uterine carcinoma cells. Compounds 3c,d displayed moderate B16F10 and HeLa inhibitory activity levels (3c: IC50 = 45 μM in B16F10 cells and 34 μM in HeLa cells, 3d: IC50 = 50 μM in B16F10 cells and 32 μM in HeLa cells).

New dimeric Schiff base quinoline complexes: Synthesis, spectral characterization, electrochemistry and cytotoxicity

“…Pyrazole derivatives are also well established in the literature as important biologically effective heterocyclic compounds. These derivatives are the subject of many research studies due to their widespread potential pharmacological activities such as analgesic, antidepressant, antibacterial, plant growth regulatory, anti‐inflammatory and antihyperglycaemic activities . Hence, the development of improved methods for the synthesis of substituted pyrazole derivatives has acquired relevance to current research.…”

“…These derivatives are the subject of many research studies due to their widespread potential pharmacological activities such as analgesic, antidepressant, antibacterial, plant growth regulatory, anti‐inflammatory and antihyperglycaemic activities. [ 13–18 ] Hence, the development of improved methods for the synthesis of substituted pyrazole derivatives has acquired relevance to current research. In the research work reported here, the synthesis, characterization and cytotoxic studies of novel metal(II/III) complexes containing a Schiff base derived from 2‐hydrazineylquinoline and 1,3‐diphenyl‐1 H ‐pyrazole‐5‐carbaldehyde are described.…”