Synthesis and biological activity of anticoccidial agents: 5,6-Diarylimidazo[2,1-b][1,3]thiazoles

Protein Kinases as Suitable Targets for Combating Eimeria spp

“…The in-vitro activity of all derivatives bearing a basic nitrogen in the substituent at 6position of the indole system (R2) were in the subnanomolar range. Although the level of potency of the compounds of this series did not match that of the most potent imidazopyridines, the 2,3-diarylindoles nevertheless hold promise for the development of anticoccidial agents [26]. The optimal distance between the carbon atom at the indole 6-position and the entropically restricted basic nitrogen atom was observed to be three to four atoms.…”

Synthesis of Heterocyclic Analogs of α‐aminoadipic Acid and its Esters Based on Imidazo[2,1‐b][1,3]Thiazole

“…In recent years, functionalized imidazo [1,2-b] [1,3]thiazole derivatives have been explored as inhibitors of mitochondrial NAHD dehydrogenase [1] and as antitumor [2], antimicrobial [3], cardiodepressant [4], and anticoccidial agents [5].…”

Microwave-assisted Hantzsch thiazole synthesis of N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amines from the reaction of 2-chloro-1-(6-phenylimidazo[2,1-b]thiazol-5-yl)ethanones and thioureas

“…1 As shown in Figure 1, tetramisole ( A ) is a strong anthelmintic in the treatment of many nematodes. 2 Thieno[3,2- d ]pyrimidinone ( B ) 3 and 5,6-diarylimidazo[2,1- b ][1,3]thiazoles ( C ), 4 are excellent antibacterial agents and C-2 aryl-substituted pilicides [thiazole ring-fused 2-pyridones ( D )] 5 exhibit anti-coccidial behavior. 11 C-labeled imidazo[2,1- b ]benzothiazole ( E ) 6 has been shown to be a superb fluoroprobe in PET analysis of Alzheimer’s disease.…”