Synthesis and Biological Activity of Some Novel Derivatives of 4-Amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole

Abstract

To discover new 1,2,4-triazole derivatives which may possess significant biological activities, we synthesized a series of novel 6-aryl-3-(D-galactopentitol-1-yl)-7H-1,2,4-triazolo [3,4-b][1,3,4]thiadiazines and 4-(arylmethylidene)amino-5-(D-galactopentitol-1-yl)-3-mercapto-4H-1,2,4-triazoles from 4-amino-3-(D-galactopentitol-1-yl)-5-mercapto-1,2,4-triazole. All the title compounds were characterized by elemental analysis, IR, 1 H-and 13 C-NMR. Plant growth-regulating activity tests showed that these compounds have remarkable effects on the growth of radish and wheat.

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

“…Several triazoles have been reported to possess antibacterial (Singh et al, 2006), antifungal (Rezaei et al, 2009), antitumor (Guo-Qiang et al, 2008, plant growth regulating (Jin et al, 2007) and cytotoxic (Bagihalli et al, 2008) activities.…”

Synthesis and root growth activity of some new acetylhydrazinecarbothioamides and 1,2,4-triazoles substituted with 5H-dibenzo[a,d]annulene moiety

“…It is well documented that 1,2,4-triazole 1542 SOCEA et al derivatives possess antimicrobial, antifungal, tuberculostatic, analgesic and carbonic anhydrase inhibitor activities. [9][10][11][12][13] Motivated by these facts and as a continuation of previous work, 2,14-18 the synthesis, characterization and action on vegetal cell division of new hydrazinecarbothioamides and 1,2,4-triazole derivatives containing the 5H-dibenzo[a,d]- [7]annulene moiety are presented herein.…”

Synthesis and Biological Activities of Some Schiff's Bases from 4-amino-3-(3-hydroxybutyl)-1H-1, 2, 4-triazole-5-thione

“…2 The thiocarbohydrazide (3.18 g, 30 mmol) was added to a solution of 4-methyl--butyrolactone (1.89 mL, 20 mmol) in …”

“…The title compounds show a more pronounced inhibiting effect on the growth of wheat at higher concentration than the similar compounds our group synthesised in the past. 2,14 It is worthy of further study to establish a relationship between structure and activity.…”

“…[1][2][3][4][5] Some Schiff's bases of 1, 2, 4-triazoles possess excellent biological activities, which have been attracting many researchers' attention in recent years. [6][7][8] In continuation of our studies on N-bridged heterocycles, 9,10 we report here the synthesis and biological activities of some Schiff's bases from 4-amino-3-(3-hydroxybutyl)-1H-1, 2, 4-triazole-5-thione.…”