Synthesis and biological evaluation of some new class of benzothiazole–pyrazole ligands containing arene ruthenium, rhodium and iridium complexes

Shadap, Lathewdeipor; Tyagi, Jaya Lakshmi; Poluri, Krishna Mohan; Новиков, С. А.; Lo, Chun-Wan Timothy; Mozharivskyj, Yurij; Kollipara, Mohan Rao

doi:10.1007/s11243-020-00439-z

Cited by 9 publications

(2 citation statements)

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“…[ 19 ] Similar studies on benzothiazole–pyrazole derivatives reported enhanced antibacterial and antioxidant activity on the administration of metal moieties wherein almost negligible activity was reported by the parent ligand. [ 21 ]…”

Section: Introductionmentioning

confidence: 99%

“…[19] Similar studies on benzothiazolepyrazole derivatives reported enhanced antibacterial and antioxidant activity on the administration of metal moieties wherein almost negligible activity was reported by the parent ligand. [21] Schiff base-derived metal complexes are well renowned to exhibit their binding ability towards drug proteins with the serum albumins. [22,23] The abundance of serum albumins proteins in the blood is employed in the drug transportation of drug molecules in the body human.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, structural elucidation, biological screening, and density functional theory calculations of Cu(II), Ni(II), Mn(II), and Co(II) complexes of 20 Z‐N‐((Z)‐2‐(6‐nitrobenzo[d]thiazol‐2‐ylimino)‐1,2‐diphenylethylidene)‐5‐nitrobenzo[d]thiazol‐2‐amine Schiff base ligand

Shekhar

Sharma

Okolie

et al. 2022

Applied Organom Chemis

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The emerging Schiff base‐derived metal complexes are the building blocks for biomedical applications. Herein, novel Schiff base N,N′‐[(1Z,2Z)‐1,2‐diphenylethane‐1,2‐diylidene]bis(6‐nitro‐1,3‐thiazol‐2‐amine) and corresponding Cu(II), Ni(II), Mn(II), and Co(II) metal complexes were successfully synthesized and characterized. The characterization of ligand and corresponding metal complexes was carried out by employing elemental analysis, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy, mass spectroscopy, Fourier transform infrared spectroscopy (FTIR) analysis, molar conductance, magnetic susceptibility measurements, electronic spectra, electronic paramagnetic resonance (EPR) and density functional theory (DFT) studies. DFT calculations at B3LYP/6‐311+G** level of theory have been executed to examine the equilibrium geometry of the ligand and metal complexes. Furthermore, total energy, highest‐occupied molecular orbital (HOMO) and lowest‐unoccupied molecular orbital (LUMO), and Mulliken atomic charges were reckoned. Tetrahedral geometry was observed in the case of the Ni(II) complex, and octahedral geometries were discerned for Cu(II), Mn(II), and Co(II), complexes. Docking studies were performed against the newly synthesized analogs with the active site of Escherichia coli (PDB ID: 3t88), Staphylococcus aureus (PDB ID: 3q8u), Candida Albicans (PDB ID: 3qlw), and Aspergillus flavus (PDB ID: 4ynt) receptors to recognize the interactions between complexes and identify their probable binding sites. Synthesized analogs were examined for in vitro antimicrobial activity employing both minimum inhibitory concentration and disk diffusion method against the aforementioned pathogens. The result for these pathogens suggested metal compounds evince higher activity in comparison to the free ligand.

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Section: Introductionmentioning

confidence: 99%