2021
DOI: 10.1039/d1md00079a
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Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors

Abstract: Key modifications of previous sialyltransferase inhibitors increased their activity against hST6Gal I and has further implications for synthetically accessible ST inhibitor design.

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Cited by 4 publications
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“…1,2,3-Triazole as one of the most important classes of nitrogen-containing heterocycle exhibits potent anticancer activity 6 . 1,2,3-triazole-benzoxazole hybrid 1 ( Figure 1 ) displayed antiproliferative activity against SKBr3, HepG2, and HeLa cells with IC 50 values of 7.1, 11.2, and 6.8 μg/mL 7 .…”
Section: Introductionmentioning
confidence: 99%
“…1,2,3-Triazole as one of the most important classes of nitrogen-containing heterocycle exhibits potent anticancer activity 6 . 1,2,3-triazole-benzoxazole hybrid 1 ( Figure 1 ) displayed antiproliferative activity against SKBr3, HepG2, and HeLa cells with IC 50 values of 7.1, 11.2, and 6.8 μg/mL 7 .…”
Section: Introductionmentioning
confidence: 99%