Synthesis and Biological Investigations of Pyrimidine Derivatives

Cieplik, Jerzy; Pluta, Janusz; Meler, Grazyna

doi:10.1002/ardp.19973300802

Cited by 9 publications

(4 citation statements)

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“…Pyrimidine derivatives have been reported as anti-microbial [3], analgesic, anti-viral, anti-inflammatory [4], anti-HIV [5], anti-tubercular [6], anti-tumour [7], anti-malarial [8], cardiovascular [9] agents. Pyrimidine derivatives have been found to exhibit cytostatic [10][11][12], immune modulating [13,14] and antibacterial properties [15][16][17][18][19][20][21]. In particular, studies concerning the synthesis of pyrimido [4,5-d]-1,3-oxazines [22] showing considerable similarity to quinoline chemotherapeutic agents with an antibacterial effect.…”

Section: Introductionmentioning

confidence: 99%

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Arulkumaran¹,

Sundararajan²,

Manikandan³

et al. 2014

ILCPA

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A series of 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamide compounds have been synthesized from various substituted dithioacetal and guanidine. The purities of these compounds were checked by their physical constants, UV, IR, NMR and MASS spectral data. The IR and 1 HNMR spectral data of these compounds have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed.

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Section: Introductionmentioning

confidence: 99%

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Arulkumaran¹,

Sundararajan²,

Manikandan³

et al. 2014

ILCPA

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“…Results of previous research on synthesis and biological properties of pyrimidine ring have demonstrated that the system is capable of extremely potent biological activity. The obtained derivatives revealed both cytostatic [1,2], immunomodulating [3,4] and first of all antibacterial [5,6,7] properties. That is why we found usefbl to carry out a number of syntheses aiming at obtaining 5-substituted pyrimidine sulphonamides.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of New Sulphonamides of Pyrimidine

2000

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“…The antimicrobial studies on the Schiff and Mannich bases of isatin and its derivatives with pyrimidine analogues were considered important from the fact that pyrimidine compounds have shown antibacterial [94,95], antifungal [96], antimycobacterial [97] and HIV RT inhibitory [98,99] properties. The N-Mannich bases of 3-[4'-(4"-chlorophenyl)-6'-(4"'-methylphenyl) pyrimidin-2'-yl] imino isatin were synthesized and their antibacterial, antifungal, antitubercular and anti-HIV activities were carried out.…”

Section: Isatinimino Compounds a Potential Lead For The Effective Trmentioning

confidence: 99%

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

Sriram

Yogeeswari²

2003

CMC

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HIV is the most significant risk factor for many opportunistic infections like fungal, tuberculosis, etc. The intense media coverage of AIDS puts the public on an emotional roller caster, and inflated promises are engendered by each success. For the moment drugs acting as both HIV-reverse transcriptase inhibitors along with antimicrobial properties are one of the brightest hope. The Non-nucleoside reverse transcriptase inhibitors (NNRTIs) appear ideally suited for further development in the chemoprophylaxis and therapy of HIV infections. In recent years, isatinimino compounds have been reported to exhibit broad-spectrum chemotherapeutic properties that include anti-HIV, antituberculous, antifungal and antibacterial activities. Hence these leads should be regarded as structural hits in the search for more potent antimicrobial compounds with broad-spectrum chemotherapeutic properties for the effective treatment of HIV / AIDS. This review focuses on the design of isatinimino compounds, which resemble the NNRTIs for the development of an ideal anti-HIV drug.

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Synthesis and Biological Investigations of Pyrimidine Derivatives

Abstract: The study concerns new syntheses of 5-hydroxy ether and 5-aminohydroxy ether derivatives of pyrimidine. When tested for antibacterial activity, some of the compounds exhibited promising effects.

Cited by 9 publications

References 1 publication

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

Synthesis and Antibacterial Activity of New Sulphonamides of Pyrimidine

Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS

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