2021
DOI: 10.3390/pharmaceutics14010049
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Synthesis and Characterization of a New Norfloxacin/Resorcinol Cocrystal with Enhanced Solubility and Dissolution Profile

Abstract: A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms with the same (1:1) Norfloxacin/resorcinol stoichiometry. The solubility of Norfloxacin and the hydrated cocrystal were determined by the shake-flask method. While Norfloxacin has a solubility of 0.32 ± 0.02 mg/mL, the cocrystal has a solubility of 2.64 ± 0.39… Show more

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Cited by 20 publications
(13 citation statements)
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“…Resorcinol has been used as a coformer to improve the dissolution, solubility and stability of drug cocrystals. 24–26…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Resorcinol has been used as a coformer to improve the dissolution, solubility and stability of drug cocrystals. 24–26…”
Section: Methodsmentioning
confidence: 99%
“…Resorcinol has been used as a coformer to improve the dissolution, solubility and stability of drug cocrystals. [24][25][26] 2.3. Single crystal X-ray diffraction X-ray reflections on the multi-component solid forms were collected on a Bruker SMART APEX CCD diffractometer equipped with a graphite monochromator and a Mo-Kα finefocus sealed tube (λ = 0.71073 Å) operated at 1500 W power (40 kV, 30 mA).…”
Section: Synthesis and Crystallizationmentioning
confidence: 99%
“…Fael H et al have prepared co-crystal of norfloxacin-based solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. Norfloxacin has a solubility of 0.32 ± 0.02 mg/mL, whereas the co-crystal has a solubility of 2.64 ± 0.39 mg/mL, approximately 10-fold higher [74]. Machado Cruz et al develop a new co-crystal of the poorly water-soluble antifungal agent itraconazole.…”
Section: Case Study Of Multicomponent Co-crystals and Drug-drug Co-cr...mentioning
confidence: 99%
“…Co-crystal is a solids-state form of crystalline single-stage materials made of at least two or more different molecular or ionic compounds commonly in a stoichiometric proportion that are neither solvated nor simple salts. [3,4] The comprehensive definition of co-crystals consists of two or more components that form a unique crystalline form structure, which has extraordinary properties. The design and synthesis of Crystal engineering is the plan and combination of solid-state structures, because of the agreement and utilization of intermolecular interaction, with required properties.…”
Section: Introductionmentioning
confidence: 99%