Synthesis and Characterization of Biodegradable Film Chitosan and Carboxymethyl Chitosan to Substitute Silver Wound Healer Plaster

Abstract

Currently, wound dressing is made of fabric or polyvinyl chloride (PVC) plastics with silver as active ingredients. Residues of silver can be toxic in the environment and PVC waste is a very long decomposed by soil. Chitosan and carboxymethyl chitosan (CMC) film have been synthesized as a biodegradable material that potential to replace silver wound plasters. CMC film has been synthesized from chitosan with a wide range of molecular weight. Chitosan with high molecular weight resulting from the reflux (1a) while the low molecular weight chitosan produced from microwaves assisted organic synthesis-MAOS (1b). All chitosan and CMC are then molded into a film chitosan and CMC and their properties were analyzed by solubility test. The COOH number of the CMC is also measured by titration. The results show that the CMC were synthesized from chitosan MAOS (2b) has higher COOH group than CMC from chitosan reflux (2a). Chitosan with MAOS process is able to produce a more homogeneous and has a lower molecular weight in a short time. Chitosan 1a films are strong and rigid while chitosan films 1b and CMC films have fragile nature. Test of solubility in physiological solution showed that the CMC films lost 78.56% Massa while chitosan films 1a only 44.59%. This show that a combination of chitosan films for wound plaster with CMC films as a wound healer active ingredient is suitable for replacing the fabric wound plasters contains silver as an active ingredient.

Modification of Nias’ Cacao Pod Husk Cellulose through Carboxymethylation Stages by Using MAOS Method and Its Application as Li‐ion Batteries’ Biopolymer Electrolyte Membrane**

“…CMC is widely applied in various fields, such as a thickening agent in food, paper materials, textile materials, pharmaceutical materials, and the paint industry [23] . In others, CMC is used as a polymer electrolyte membrane, [24] reinforcer, [25] packaging, [26,27] and corrosion inhibitor [28] . CMC can be synthesized through two stages, namely the cellulose alkalization (maceration) and cellulose carboxymethylation process (etherification stage) in isopropanol [13,19,23,29–31] …”

Riboflavin Functionalized Dextrin-Sodium Alginate Based Fluorescent Sensor: Detoxification of Cu2+ and Ni2+ Ions

“…It was dried in an oven at 50 °C until constant weight was attained. 30 2.2.2. Enzyme Mediated Derivatization of Film.…”

“…The final reaction was carried out at 65 °C for 3 h. The hybrid network of polymers in the form of a film [Dex-NaAlg-cl-poly­(AAm) or DSA film) is cross-linked, and product was washed properly with double distilled water. It was dried in an oven at 50 °C until constant weight was attained …”