Synthesis and characterization of calcium oxyboroapatite with bimodal porosity

Vassilakopoulou, Anastasia; Dimos, Konstantinos; Kostas, Vasilis; Karakassides, Michael A.; Koutselas, Ioannis

doi:10.1007/s10971-016-3964-9

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…5 Besides, α-TCP has the same biocompatibility as β-TCP, but it is more soluble 6 and can be quickly hydrolyzed into calcium-deficient hydroxyapatite (CDHA) in water. 7,8 This makes α-TCP an important component in the preparation of self-curing bone cement, degradable bioceramics, and bone repair materials. 8,9 CDHA is a kind of HA, but compared to HA, its Ca/P molar ratio is between 1.5 and 1.67, which is a nonstoichiometric HA.…”

Section: Introductionmentioning

confidence: 99%

A novel synthesis method and properties of calcium-deficient hydroxyapatite/α-TCP biphasic calcium phosphate

Yuan

Wang

et al. 2022

J Biomater Appl

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Biphasic calcium phosphate (BCP) is an important research field based on calcium phosphate biomaterials. In this paper, a new synthesis method of CDHA/α-TCP BCP was studied. By controlling the addition amount of citric acid, the relative contents of CDHA and α-TCP in the BCP were controlled. BCP bone cement was prepared with different proportions of BCP as raw materials. The BCP bone cement was characterized by XRD and SEM, and evaluated by measuring setting time, compressive strength, SBF immersion, and colorimetric CCK-8 assay. The results showed that the increase of CDHA content can lead to the reduction of the setting time of bone cement and delay the degradation rate of BCP bone cement.

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Section: Introductionmentioning

confidence: 99%

A novel synthesis method and properties of calcium-deficient hydroxyapatite/α-TCP biphasic calcium phosphate

Yuan

Wang

et al. 2022

J Biomater Appl

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“…Calcium chloride (CaCl 2 •2H 2 O) and calcium oxide (CaO) obtained from the eggshell were also used as calcium sources in the similar sol-gel synthesis routes for the CHAp [110,111]. Besides, the sol-gel derived BG was investigated as possible precursor for the preparation of CHAp [112]. Finally, CHAp powders were synthesized from calcium diethoxide and phosphoric acid in ethanol via a sol-gel method [113].…”

Section: Introductionmentioning

confidence: 99%

Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

Ishikawa

Kareiva

2020

J Sol-Gel Sci Technol

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In this review article the available results about application of sol-gel synthesis method for the preparation of different calcium phosphates and composite materials are summarized. The attention is paid to calcium phosphate-containing compounds which show the biological properties and could be used as potential phosphate bioceramics in medicine. It was demonstrated that the sol-gel synthesis method is a powerful tool for the synthesis of calcium hydroxyapatite and other phosphates, and different calcium phosphate-based composites at mild synthetic conditions resulted in high reproducibility, high phase purity, and desired morphology. Thus, the sol-gel synthesis method enables the researchers to develop biomaterials with superior features in terms of biomedical applications.

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“…In this vein, boron represents an interesting chemical element capable of improving the properties of bioglasses. Boron improves the mechanical properties of glasses, especially phosphate glasses and its susceptibility to hydrolysis by the formation of B−OH bonds in water, which catalyze the bioactivity of its derivatives [13][14][15][16][17][18]. The borate glasses (free of silica) represent a good substrate for cell adhesion, proliferation, and differentiation [16,19] in vivo [20] and are capable of inducing the angiogenesis [21] and neovascularization [14,15].…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of boron-based bioglass by sol−gel process

Furlan

Correr

Russi

et al. 2018

J Sol-Gel Sci Technol

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45S5 bioglass has been widely studied in the last few decades because of its bioactivity and promising applications in the biomedical field. Boron, even few studied, represents a potential element to improve the properties of the 45S5 bioglass derivatives. The bioglasses are conventionally prepared by heat treatment of oxides and silicon. Here, the sol−gel method is proposed for the preparation of the boron-based 45S5 bioglass (45S5B) and the classical 45S5 bioglass (45S5), using watersoluble salts as raw materials. The bioglasses were characterized by FTIR, XRD, and SEM, indicating the success of the sol −gel method for preparation of the samples. The bioglasses were also tested in vitro for bioactivity in biological conditions and cytotoxicity against eukaryotic cells. The bioactivity of 45S5B was similar to the bioactivity of 45S5 bioglass, indicated by the deposition of hydroxyapatite crystals at the surface of the pristine bioglasses. The results of cytotoxicity tests revealed that the IC 50 of 45S5B (IC 50 = 7.56 mg mL −1 ) was similar to the IC 50 of 45S5 (IC 50 = 8.15 mg mL −1 ), indicating its safety for application in the biomedical field.Graphical Abstract * Eliane Trovatti ;,: 1234567890();,:Highlights • The sol−gel process was used to prepare boron-based bioglass from water-soluble salts. •The bioactivity of the boron-based bioglass was similar to the conventional bioglass. •The boron-based bioglass and 45S5 bioglass showed high in vitro bioactivity. •The boron-based bioglass was not cytotoxic against OSTEO-1 eukaryotic cells.

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Synthesis and characterization of calcium oxyboroapatite with bimodal porosity

Cited by 10 publications

References 20 publications

A novel synthesis method and properties of calcium-deficient hydroxyapatite/α-TCP biphasic calcium phosphate

A novel synthesis method and properties of calcium-deficient hydroxyapatite/α-TCP biphasic calcium phosphate

Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

Preparation and characterization of boron-based bioglass by sol−gel process

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