Synthesis and characterization of dextran coated magnetite nanoparticles for diagnostics and therapy

Abstract

Introduction: Expansion of efficacious theranostic systems is of pivotal significance for medicine and human healthcare. Magnetic nanoparticles (MNPs) are known as drug delivery system and magnetic resonance imaging (MRI) contrast agent. MNPs as drug carriers have attracted significant attention because of the delivery of drugs loaded onto MNPs to solid tumors, maintaining them in the target site by an external electromagnetic field, and subsequently releasing drugs in a controlled manner. On the other hand, it is believed that MNPs possess high potential as MRI contrast agents. The aim of this work was to payload curcumin into dextran coated MNPs and investigate their potential as theranostic systems for controlled drug delivery and MRI imaging. Methods: MNPs were synthesized as a core and coated with dextran as polymeric shell to provide steric stabilization. Curcumin as anticancer drug was selected to be loaded into NPs. To characterize the synthesized NPs, various techniques (e.g., DLS, FESEM, FT-IR, XRD, and VSM) were utilized. In vitro drug release of curcumin was evaluated at 37˚C at the pH value of 5.4 and 7.4.The feasibility of employment of dextran coated MNPs as MRI contrast agents were also studied. Results: Formulations prepared from dextran coated MNPs showed high loading (13%) and encapsulation efficiency (95%). In vitro release study performed in the phosphate-buffered saline (PBS, pH= 7.4, 5.4) revealed that the dextran coated MNPs possess sustained release behavior at least for 4 days with the high extent of drug release in acidic media. Vibrating sample magnetometer (VSM) analysis proved the superparamagnetic properties of the dextran coated MNPs with relatively high-magnetization value indicating that they were sufficiently sensitive to external magnetic fields as magnetic drug carriers. Furthermore, dextran coated MNPs exhibited high potential as T2 contrast agents for MRI. Conclusion: Based on our findings, we propose the dextran coated MNPs as promising nanosystem for the delivery of various drugs such as curcumin and MRI contrast agent.

An alternative choice of lidocaine-loaded liposomes: lidocaine-loaded lipid–polymer hybrid nanoparticles for local anesthetic therapy

“…Complete release of drugs were achieved at 72 and 48 h, respectively. This could contribute to the using of CS which incorporated LA and let it release in a more sustained rate (Khalkhali et al, 2015). The drug release profile exhibit the biphasic patterns, initial about 40% burst release of drug in 8 h might be attributed to that of surface bound and superficial embedded drug in CS nanoparticles, and later sustained drug release up to 72 h was observed due to strong cross-linking complex of CS resulting into denser particle which retards LA release due to swelling of CS which lowers the membrane permeability for LA (Shirsat et al, 2015).…”

Magnetic drug delivery systems

“…Therefore, to reduce toxicity, the iron core is generally coated with biocompatible materials such as dextran, DMSA, PEG, or polystyrene [57][58][59], which will be de-scribed in detail in the next section. Researchers even hope to use biocompatible modifications to avoid unnecessary tissue aggregation and cell endocytosis, thereby ensuring the biosafety of the MDDS.…”

“…Dextran-modified MNPs can increase the half-life of the drug under physiological conditions. Many dextran-coated MNPs have been prepared for use as MRI contrast agents and targeted drug delivery carriers because they have good biocompatibility [58,59,87,88]. Dextran can also be coated on hybrid MNPs.…”

Pengendalian Suhu Ultrasonikasi Pada Pelapisan Nanopartikel Magnet (Fe3O4) Dengan Kitosan

“…Dengan teknik pengadukan yang lebih cepat misalkan ultrasonikasi, dapat diperoleh partikel magnetik terlapis PLA dengan ukuran nanometer (Yulianti, Sulungbudi, dan Mujamilah 2009). Ukuran dan distribusi ukuran nanopartikel terlapis PLA juga akan dipengaruhi oleh waktu proses (Hapsari et al 2010).…”