Synthesis and characterization of hydrophilic polymer nanoparticles using n-isopropylacrylamide (NIPAM) via emulsion polymerization technique

Azmi, Nurul Syafika; Kamaruddin, Nur Nasyita; Kassim, Syara; Harun, Noor Aniza

doi:10.1088/1757-899x/440/1/012008

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…Preparation of PNIPAM Particles via Emulsion Polymerization. Emulsion polymerization of NIPAM was performed according to the method that was previously reported by Azmi et al 26 N-Isopropylacrylamide monomer (450 mg), SDS (0.225 mg), and Triton X-100 (1 mg) as surfactants, BIS (0.065 mg) as a cross-linker, and NaHCO 3 (0.02 mg) were dispersed in DI water (50 mL). The prepared solution was transferred into a 250 mL four-neck roundbottom reactor equipped with a magnetic stirrer, a refluxcondenser, argon gas inlet, and thermometer.…”

Section: Methodsmentioning

confidence: 99%

MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer

et al. 2020

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In recent years, the exploitation of magnetic nanoparticles in smart polymeric matrices have received increased attention in several fields as site-specific drug delivery systems. Here, ultrasonic-assisted emulsion copolymerization of N-isopropylacrylamide (NIPAM) and 2-(N,N-diethylaminoethyl) methacrylate (DEAEMA) in the presence of Fe3O4 nanoparticles was employed to prepare pH- and temperature-responsive magnetite nanocomposite particles (MNCPs). The obtained MNCPs were fully characterized by TEM, DSC, FT-IR, VSM, and XRD techniques. They had an average particle size of 70 nm with a lower critical solution temperature of 42 °C and superparamagnetic properties. In addition, MNCPs were loaded with methotrexate (MTX) as an anticancer drug, and their in vitro drug release was studied in different pH values and temperatures and in the presence of an alternating magnetic field. Noteworthy that the highest rate of MTX release was observed at pH 5.5 and 42 °C. Cell viability of the treated MCF-7 human breast cancer cell line with free MTX, MNCPs, and MTX-loaded MNCPs or in combination with magnetic hyperthermia (MHT) and water-based hyperthermia was comparatively studied. The obtained results showed about 17% higher antiproliferative activity for the MTX-loaded MNCPs accompanied by MHT relative to that of free MTX.

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Section: Methodsmentioning

confidence: 99%

MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer

et al. 2020

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“…CMC is defined as the concentration of surfactant above the micellization becomes thermodynamically favorable and any additional surfactant added to the system forms micelles [72]. From the research, it can be proved that different CMC did affect the emulsion polymerization, in which different morphology detected by the scanning electron microscope (SEM) and different thermal stability was obtained via thermogravimetric analysis (TGA) [23]. Besides, it proves that the equivalent CMC for the surfactant showed more stability in terms of thermal degradation based on the highest onset temperature.…”

Section: Figure 6 Emulsion Polymerization Processmentioning

confidence: 99%

“…When the temperature is below LCST, the hydrophilic amide group dissolved by the water molecules resulting in the PNIPAM soluble in water caused by a highly structured hydration shell made by hydrogen bonding and made it remains in a coil-like conformation. While it will collapse into coil-to-globule when the temperature is elevated because the hydrogen bonding is weakened and following that the interactions among the hydrophobic group become strong and result in the release of water from structure [27,23]. On top of that, it is often misinterpreted that PNIPAM is hydrophobic above LCST, although it contains both hydrophobic and hydrophilic moieties [22].…”

Section: Poly (N-isopropyl Acrylamide) (Pnipam)mentioning

confidence: 99%

RECENT TRENDS IN DIFFERENT TYPES OF SYNTHETIC HYDROPHILIC POLYMER NANOPARTICLES, METHODS OF SYNTHESIS & THEIR APPLICATIONS

Norazman,

Mujad,

Mocktar

et al. 2023

Jurnal Teknologi

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Numerous types of hydrophilic polymer nanoparticles (NPs) have recently become research hotspots because of their ability to dissolve in water and can be adapted with respect to physical, chemical, and biological properties to meet the requirements of different applications. Synthetic hydrophilic polymeric NPs had successfully gained much attention because of their unique physicochemical properties, such as low toxicity, biodegradability, bioavailability, and support material for extensive swelling in water. These synthetic hydrophilic polymers NPs create new opportunities to produce water-soluble polymer types that would be able to imitate the structure and function of biological polymers. Several synthetic hydrophilic polymer NPs that gain high interest recently including poly(N-isopropyl acrylamide) (PNIPAM), poly(ethylene glycol) (PEG), poly(vinyl alcohol) (PVA) and poly(N-(2-hydroxypropyl) methacrylamide (PHPMA) are reviewed in this paper. Furthermore, various synthesis methods to produce synthetic hydrophilic polymer NPs for instance emulsion polymerization, microemulsion polymerization and inverse miniemulsion polymerization are highlighted, and a brief overview on their recent applications especially in medical applications are also be discussed thoroughly in this review.

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“…The composites were washed several times with deionized water show a typical FT-IR spectrum of PNIPAM. The most intense peak at 1677 cm -1 is attributed to C=O and the second most intense peak at 1563 cm -1 is due to amide groups (N-H and C-N); characteristic bimodal peaks of isopropyl groups could be observed at 1390, and 1379 cm -1 ; methylene peaks could be seen at 2987 and 2942 cm -1 (18); the broad peak at 3310 cm -1 is caused by N-H stretching (19). However, the peaks of PNIPAM@60 are much more intensive than those of PNIPAM@20 because heating at higher temperature provides more oxygen-involved radicals to readily crosslink NIPAM.…”

Section: Sponge Fabricationmentioning

confidence: 99%

Thermoresponsive hydrogels for atmospheric water vapor harvesting

Cherukupally

Hao

Zhang

2021

Preprint

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Currently, freshwater scarcity is a global challenge that is threatening four billion people across the world. To satisfy people’s increasing freshwater demand, harvesting atmospheric water from the air could be an alternative way. This work developed copolymer P(NIPAM-co-15%BzDMA) hydrogels to harvest atmospheric water vapor. Two methods were investigated to improve its adsorption performance: decreasing synthesis temperature below the LCST and copolymerizing with the optimum amount of quaternary ammonium salt (QAS). We found these two methods can effectively improve the water vapor uptake. After copolymerizing NIPAM with 15% QAS at 20°C, the water vapor uptake could be increased by almost 20% to 232 mg/g at 20°C and P/P0 of 0.75 compared with pure PNIPAM prepared at 60°C (194 mg/g). The significant increase can be attributed to the more uniform porous structure and the hygroscopicity of QAS. After coating PNIPAM onto the PESPU sponge skeleton, the PESPU-PNIPAM_60 could adsorb 180 mg/g gas water at 20°C and P/P0 of 0.75, and the modified sponges inherit the switchable wettability from PNIPAM. This research provides polymer processing parameters and their character for harvesting water vapor from the air with hydrogels.

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Synthesis and characterization of hydrophilic polymer nanoparticles using n-isopropylacrylamide (NIPAM) via emulsion polymerization technique

Cited by 7 publications

References 12 publications

MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer

MTX-Loaded Dual Thermoresponsive and pH-Responsive Magnetic Hydrogel Nanocomposite Particles for Combined Controlled Drug Delivery and Hyperthermia Therapy of Cancer

RECENT TRENDS IN DIFFERENT TYPES OF SYNTHETIC HYDROPHILIC POLYMER NANOPARTICLES, METHODS OF SYNTHESIS & THEIR APPLICATIONS

Thermoresponsive hydrogels for atmospheric water vapor harvesting

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