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Nanoparticles are defined as submicron-size solid between 100 to 500 nm that can be either biodegradable or non-biodegradable [1]. Nanoparticles can be constructed from various materials (e.g. polymers, lipids, metals, magnetic) and widely utilized in various industrial application like optical [2], catalyst [3], thermal [4], electrical [5], mechanical [6] and magnetic function [7]. In particular, polymeric nanoparticles have received great attention on account of their versatility in which they can host a wide range of active components including chemotherapeutics, contrast agents, proteins and nucleic acids, for various bio-medical applications [8]. The criteria for the ideal polymeric nanoparticles especially in the development of biomedical fields should be easy to synthesize, inexpensive, biocompatible and biodegradable, non-toxic and water soluble [9]. Hydrophilic polymer nanoparticles are the type of polymer chain that contains substitution of hydrophilic groups at the backbone either from anionic, cationic or amphoteric. This type of polymer can be divided into two main types, synthetic and natural. Nowadays, synthetic

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