Synthesis and Characterization of Konjac Glucomannan-Graft-Polyacrylamide via γ-Irradiation

Abstract

The synthesis of konjac glucomannan-graft-polyacrylamide (KGM-g-PAM) was carried out at 25°C by γ-irradiation under a N2 atmosphere. The effects of absorbed radiation dosage and monomer concentration on grafting yield and water absorbency were studied. The grafted copolymers were characterized using Fourier Transform Infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR), x-ray diffraction (XRD), thermogravimetric analysis (TGA) and gel permeation chromatography (GPC). The grafting yield was observed to increase with increasing absorbed dosage and monomer concentration. Compared with the original KGM, the grafted copolymers exhibited better thermal stability and water absorbency. The results suggest that γ-irradiation is convenient and efficient for inducing graft copolymerization of KGM and acrylamide (AM).

Deacetylation affects the physical properties and bioactivity of acemannan, an extracted polysaccharide from Aloe vera

“…Alkaline deacetylation of glucomannan extracted from Amorphophallus konjac changed the physicochemical, mechanical, viscoelastic, and structural characteristics of its three-dimensional network (Solode-Zaldívar, Tovar, Borderías, & B, 2014;Xu, Yang, Jiang, Sun, Shen, & Pang, 2008;Xu et al, 2008). Acetylation and deacetylation is a mechanism used in eukaryotes and prokaryotes to control protein structure and activity.…”

Microwave assisted synthesis of polyacrylamide grafted dextrin (Dxt-g-PAM): Development and application of a novel polymeric flocculant

“…Synthesis of grafted polymers essentially involves free radical mechanism. The free radicals can be generated in a variety of ways; the most effective approaches are the use of free radical initiator [3][4][5][6], by using high energy radiations such as ϒ-rays [13,14] or by use of microwave irradiation [15][16][17][18]. Among various methods of synthesis, microwave irradiation exhibits the most potential to synthesize the grafted polymers, because as the free radicals are generated by means of microwave photons, the chain opening of polysaccharide backbones does not take place hence rigidity of the polysaccharide chain is maintained giving higher percentage of grafting.…”

Aplicações farmacêuticas de polímeros

“…Estes sistemas apresentam baixa toxicidade, boa estabilidade, baixo custo, biodegradabilidade específica e inúmeras possibilidades de modificações moleculares. Além dos polissacarídeos, blendas de dois ou mais poliésteres biodegradáveis vem ganhando importância [49,50,[149][150][151][152][153][154] . A preparação de polímeros impressos molecularmente (PIM) é uma estratégia promissora na elaboração de matrizes inteligentes para a liberação de fármacos.…”