Synthesis and characterization of molecularly imprinted polymer of N-maleoylchitosan-grafted-2-acrylamido-2-methylpropanesulfonic acid and its controlled delivery and recognition of bovine serum albumin

Anirudhan, T.S.; Sandeep, S.

doi:10.1039/c1py00059d

Cited by 51 publications

(31 citation statements)

References 21 publications

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“…In the MACTS spectrum, the newly formed peaks at 1635 and 1705 cm À1 correspond to the stretching mode of carbon-carbon double bond and CQO of the carboxyl group of maleic acid, respectively. The peak at 1735 cm À1 confirms the stretching mode of CQO of the ester bond formed due to the graft reaction of CTS and MAH 9. In the spectrum of MMT, the absorption band at 1069 cm À1 is ascribed to the Si-OH bond which is shifted to 1016 cm À1 with decreased intensity in MACTS/MMT.…”

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confidence: 53%

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Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Anirudhan

Sandeep

2011

New J. Chem.

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A novel pH-sensitive composite hydrogel (CH) namely 2-Acrylamido-2-methylpropane sulfonic acid (AMPS) grafted N-maleoylchitosan (MACTS) intercalated montmorillonite has been synthesized by in situ intercalation graft copolymerization of AMPS with MACTS intercalated MMT (MACTS/MMT) by using potassium persulfate (KPS) as a free radical initiator, in the presence of N,N-methylenebisacrylamide (MBA) as a crosslinking agent. A hydrophilic anticancer drug, 5-fluorouracil (5-FLU), has been chosen to investigate the loading and release properties of the CH. The CH formation and 5-FLU loading ability of CH have been confirmed by FTIR. X-Ray diffraction (XRD) analysis supports the intercalation reaction of MACTS with MMT, since after intercalation reaction there is an increase in basal spacing. A scanning electron microscopy (SEM) image of drug loaded CH shows a smoother surface whereas blank CH has a cracked and rough surface, this reveals the high affinity of 5-FLU to CH. The encapsulation efficiency of CH reaches the maximum value of 94.0% with CH prepared using 4.0 g of MACTS/MMT, 1.5 g of AMPS, 0.75 g of MBA and 75.0% of drug loading. Swelling profiles obtained show that the CH swelling rate increases with increase of pH up to 6.4 and then starts to decrease. Release profiles of 5-FLU from CH have been studied under both simulated gastric and intestinal pH conditions. The results obtained show that the release rate of the loaded drug molecules was slow at pH 2.4 but increased significantly at pH 7.4. The cell viability test displayed that the 5-FLU loaded CH exhibited an enhanced cell inhibition than that of pure 5-FLU. The studies described in the paper demonstrate the potential viability of a pH-sensitive CH carrier for colon specific anticancer drugs.

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“…The proposed reaction scheme is shown in Scheme 2. 9 and is obviously weakened after the polymerization reaction. This indicates the participation of the vinyl bond of MACTS in the polymerization reaction.…”

Section: Mechanism Of Amps-g-macts/mmt Composite Formationmentioning

confidence: 97%

Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Anirudhan

Sandeep

2011

New J. Chem.

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“…Two samples have entirely different surface morphological features. From the earlier reports it is clear that CT has fibrous lamellar structure [29]. CT-Na 3 Cit-CAc has a smooth, fluffy, and homogeneous surface.…”

Section: Characterizationmentioning

confidence: 96%

Synthesis and Characterization of Chitosan Based Multilayer and pH Sensitive Co-Polymeric System for the Targeted Delivery of 5-Fluorouracil, an In Vitro Study

Anirudhan¹,

Rejeena²

2014

International Journal of Polymeric Materials and Polymeric Biom

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The principle aspiration is to develop a core shell carrier system for 5-Fluorouracil. Trisodiumcitrate crosslinked chitosan containing 5-Fluorouracil coated with cellulose acetate acts as core and copolymer of N-vinyl-2-pyrrolidone, 2-hydroxyethylmethacrylate, and itaconic acid act as shell. SEM, FTIR, and XRD studies were undertaken to characterize the samples. Swelling experiments were performed as a function of time, temperature, pH, and in simulated gastric and intestinal pH. Swelling factor was calculated for three different ions. Drug loading efficiency and in vitro release studies was done and compared. Drug delivery mechanism was found out by using Peppa's equation.

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“…A brief synopsis of the different types of protein and biomacromolecular surface‐imprinted monoliths and particles/beads is shown in Tables and , respectively, including the various surface imprinting strategies and characterization techniques that have been utilized.…”

Section: Imprinting Of Peptides and Proteins For The Use In Solid‐phamentioning

confidence: 99%

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

Boysen

2018

J of Separation Science

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This review documents recent advances in the design, synthesis, characterization, and application of molecularly imprinted polymers in the form of monoliths and particles/beads for the use in the separation and analysis of proteins with solid‐phase extraction or liquid chromatography. The merits of three‐dimensional molecular imprinting, whereby the molecular template is randomly embedded in the polymer, and two‐dimensional imprinting, in which the template is confined to the surface, are described. Target protein binding can be achieved by either using the entire protein as a template or by using a protein substructure as template, that is, a peptide, as in the "epitope" approach. The intended approach and strategy then determine the choice of polymerization method. A synopsis has been provided on methods used for the physical, chemical, and functional characterizations and associated performance evaluations of molecularly imprinted and nonimprinted control polymers, involving a diverse range of analytical techniques commonly used for low and high molecular mass analytes. Examples of recent applications demonstrate that, due to the versatility of imprinting methods, molecularly imprinted monoliths or particles/beads can be adapted to protein extraction/depletion and separation procedures relevant to, for example, protein biomarker detection and quantification in biomedical diagnostics and targeted proteomics.

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Synthesis and characterization of molecularly imprinted polymer of N-maleoylchitosan-grafted-2-acrylamido-2-methylpropanesulfonic acid and its controlled delivery and recognition of bovine serum albumin

Cited by 51 publications

References 21 publications

Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Synthesis and characterization of a novel pH-controllable composite hydrogel for anticancer drug delivery

Synthesis and Characterization of Chitosan Based Multilayer and pH Sensitive Co-Polymeric System for the Targeted Delivery of 5-Fluorouracil, an In Vitro Study

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

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