Synthesis and Characterization of New Azo Dyes Based on Thiazole and Assess the Biological and Laser Efficacy for Them and Study their Dyeing Application

Abstract

The aim of this work describes the synthesis of disperse dyes in the derivative of 2-amino -4-hydroxy thiazole, which can be used as dyes for polyester fabrics with orange and red color They were obtained by preparing, (2-amino-4hydroxy-thiazole), then the latter compound was diazotization and couplings to produced (compound III and IV), Which were introduced by another coupling with diazonium salt of compound I diazotization to synthesize disperse (VII,VIII). The synthesized heterocyclic and synthesized dyes were studied by UV Spectroscopy, FT-IR, 1 H-NMR and 13 C-NMR. The substituted dyes Penetrate with good depth on polyester fabrics with a shade of orange and red colors, respectively. That increase heteroatoms and the conjugation in the dyes structure lead to high redshifts and the brightness of shades, color stability is high and fastness properties. The antibacterial activities were studied against different kinds of bacteria, namely Eschershia coli and Klebsiella Pneumonia Gram (-) ve, Staphylococcus aureus and Staphylococcus epidermidis Gram (+) ve. In addition, evaluation of laser efficacy was showed for the compounds (I,III,IV,VII,VIII) were radiated by laser for (10, 20, 30) seconds, It was observed that the prepared compounds were not affected and did not polymerize or degradation when measuring melting point and color.

Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one

“…The yield ratio is higher, the byproducts are very little or no, and the time taken for the reaction is very short compared to the time taken by the traditional method (reflux), as well as the ease of isolating the products prepared by microwave technology compared to the traditional method (reflux). As for the physical properties of the compounds prepared by the microwave method, the melting point, color and solubility are identical to the compounds prepared by the traditional method (reflux) [18], as shown in table (4).…”

“…These compounds are considered one of the most effective cyclic compounds because they possess four free pairs of electrons for four nitrogen atoms of the electron propellant compounds [3]. This Imidazolidin-4one is prepared by cyclic addition between Schiff base compounds and alanine [4]. Imidazolidin-4-one compounds and their derivatives possessed great importance, especially in the biological field, as the prepared compounds showed anti-bacterial, anti-fungal, and anti-viral efficacy [5].…”

Preparation and characterization of new compounds for schiff base derived from furfural, study of some physical applications and evaluation of their biological activity

“…When performing the UV spectroscopy of the Schiff bases, we observed the appearance of an absorption band (π→π*) with a small wavelength and greater intensity; Because there are pathologically shifted (C=C) bonds of the derivatives of Schiff bases within the range (238 nm). Also, an absorption band (n→π*) with a large wavelength and less intensity appeared because of unshared electron pairs on the oxygen and nitrogen atoms and the bathochromic displacement of the presence of oxo and cascade groups within the range (402 nm) [24].…”

Determination of cefdinir in pharmaceutical preparations by oxidative conjugation method

“…The stoichiometry of the product: The "equivalence of the product" was studied for the interaction of Cefdinir with the reagent under optimal conditions by the molar ratio method, as the initial concentration used was 1×10 -2 , as well as by the continuous change method at an initial concentration of 8×10 -2 , where the ratio of equivalence between the drug and the reagent was 7): Mole-ratio method of Cef and Continuous variation method of Cef Suggested interaction: The proposed reaction can be based on a condensation reaction between Cefdinir and p-Aminobanzoicacid in a base medium to produce a dense, yellow colored product [29] Application of the proposed methods: In table 5, the result of determination of (Cef) in the pharmaceutical preparations (as tablet) Determination of (Cef) by 2,4 Dipyridin: After conducting a preliminary test, the best conditions were determined by adding 0.5 ml of the oxidizing agent at a concentration of 0.001 M to 4 ml of cefdinir at a concentration of 250 mcg / ml in a 10ml capacity, followed by 0.5 ml of the reagent at a concentration of 0.01 M. Add 0.5 ml sodium hydroxide at a concentration of 1 mo, then top up with distilled water to achieve a maximum absorption limit of 0.851 at 472 nm in the laboratory vs the dummy solution, which did not show any absorption in this area.…”