Synthesis and characterization of novel 1,3-oxazepin-5(1h)-one derivatives via reaction of imine compounds with isobenzofuran-1(3h)-one

Abid, Obaid H.; Tawfeeq, Hiba Maher; Muslim, Rasim Farraj

doi:10.23893/1307-2080.aps.05525

Cited by 12 publications

(16 citation statements)

References 5 publications

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“…The presence of the carboxylic group in amino acids, pe The absorption bands at 2891 cm -1 and 2894 cm -1 for cold and hot extracts respectively, and at 1 for cold and hot extracts also belong to vibrations of homogeneous and heterogeneous stret methylene group (-CH2) or a methyl group (-CH3) 36 . The spectra showed absorption bands at 1 and 1633 cm -1 for cold and hot extracts respectively go back to vibrations of stretching of C belongs to the alkene compounds and the successive double bonds in the benzene ring in the structures 37 . As well as two bending vibration bands at 1384 cm -1 for the cold extract and 138 the cold extract belong to the hydroxyl groups (-OH); and the absorption band at 1417 cm -1 stretching vibration of the group (C-O) 38 .…”

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“…Azomethine compounds (N1-N5. The spectra showed absorption bands at 1631 cm -1 and 1633 cm -1 for cold and hot extracts respectively go back to vibrations of stretching of C=C group belongs to the alkene compounds and the successive double bonds in the benzene ring in the aromatic structures 37 . As well as two bending vibration bands at 1384 cm -1 for the cold extract and 1388 cm -1 for the cold extract belong to the hydroxyl groups (-OH); and the absorption band at 1417 cm -1 due to the stretching vibration of the group (C-O) 38 .…”

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“…The bands at 3267-3271 cm -1 and 3417-3367 cm -1 indicate for the presence of the amine group (-NH 2 ) in the synthesis of amino acids, peptides and proteins for cold and hot extracts respectively 32,39 . The presence of the carboxylic group in amino acids, peptides and proteins are the appearance of the wide absorption range (2400-3600 cm -1 ) for both extracts and maybe the presence of a carboxylic group (-COOH) in mono acidic saccharides compounds such as glucuronic acid [40][41][42][43] 3-oxazepin-5(1H see figure 12.…”

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Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from cyperus sp. rhizomes

Muslim¹,

Owaid²

2019

actapharm

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The synthesis of metallic nanoparticles has become an important issue in recent decades due to their various beneficial and unique properties and biomedical and industrial applications 1. Nanotechnology is seeking to synthesize nanoparticles have substantial biomedical applications because of their unique characteristics and their green nature due to using some medicinal plants as ABSTRACT The object of this work is biosynthesizing AgNPs from extracts of Cyperus sp. galingale rhizomes, studying their characteristics using UV-visible spectroscopy, AFM, SEM, FTIR, and EDX analyses and testing their anticancer activity (in vitro) against L20B cell line. Biosynthesizing AgNPs using various plants is considered eco-friendly, cheap, energy saving and reproducible compared with non-green methods. UV-Visible spectrum checked the surface plasmon resonance of AgNPs at 410-420 nm. FT-IR exhibited that the presence of carbonyl and hydroxyl groups in the extract of Cyperus sp. can reduce and stabilize AgNPs. EDX, SEM, and AFM analyses were applied to confirm the nature, morphology and topography of the biosynthesized AgNPs. AgNPs are spherical or irregular in shape with the average diameter of hot extract-AgNPs is 56.31 nm in comparison with cold extract-AgNPs is 92.53 nm. The hot extract-AgNPs paly a suitable role against mouse cell line (L20B) which have receptors for polioviruses better than the cold extract-AgNPs.

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Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from cyperus sp. rhizomes

Muslim¹,

Owaid²

2019

actapharm

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“…The chemistry of heterocyclic compounds has been an interesting ield of study (Verma et al, 2015) for a long time due its more application in several ields such as medicinal, pharmaceutical and selective drugs (Mohammad et al, 2017) Oxazepine stands for unsaturated non-homologous seven associated heterocycle having Oxygen in position 1 and nitrogen in position 3 along with ive carbon atoms (Abid and Ramadan, 2018). Oxazepine has three isomers bases on the location of oxygen and nitrogen atoms in the seventh ring (Abid et al, 2017).…”

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Synthesis and characterization Some of heterocyclic compounds from Nitrogen derivative

Abed

Ghanem

2019

ijrps

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This paper involves the synthesis of new oxazepine derivatives by multi-reaction steps. The first step synthesis azo derivative from 2-naphthol with 3-aminoacetophenone. The second step was the condensation reaction between ketone group of the azo compound and different primary aromatic amines (4-amino phenol, 3-nitro aniline and 4-methyl aniline) to yiled new azo Schiff base compounds (S1-S3) respectively. In the final step, Oxazepine compounds (L1-L3)and (L4-L6)were prepared from reaction imine compounds (S1-S3) with maleic and phthalic anhydride in toluene as solvent. All these derivatives were characterized by melting point, FTIR, HNMR and 13CNMR.

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“…The presence of the carboxylic group (-COOH) in amino acids is evidenced by the appearance of the broad absorption range from 2410 cm -1 to 3620 cm -1 . Moreover, a bending vibration band at 925 cm -1 is belonging to the hydroxyl group in the carboxyl group [24][25][26][27] .…”

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Biosynthesis, characterization and cytotoxicity of zinc nanoparticles using panax ginseng roots, araliaceae

Owaid¹,

Zaidan²,

Muslim³

et al. 2019

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This study aims to biosynthesize zinc nanoparticles from the aqueous extract of Panax ginseng (Red Ginseng) roots. The characteristics of ZnNPs were checked using change in color, UV-Vis, SEM, SPM, AFM, FT-IR, and EDS analyses, and assessed their cytotoxicity against L20B tumor cell line using MTT assay. The change in the solution color after 3 hr on 70 °C is from yellow to the brownish color with whitish sediments. The adsorption peak of UV-vis is 340 nm as evidence of formation the Zn nanoparticles. AFM, SEM and EDS observe shapes of zinc nanoparticles which are spherical to irregular particles with rate of size 59.76 nm. The concentration 100% Zinc nanoparticles significantly (p<0.01) recorded best inhibition percentage 41.70% against murine fibroblast cells (L20B) which have receptors of human polioviruses. Thus, this work is considered as an auspicious first test to reduce the growth of cancers using green ZnNPs of Ginseng (Panax ginseng) in vitro.

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Synthesis and characterization of novel 1,3-oxazepin-5(1h)-one derivatives via reaction of imine compounds with isobenzofuran-1(3h)-one

Cited by 12 publications

References 5 publications

Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from cyperus sp. rhizomes

Synthesis, characterization and evaluation of the anti-cancer activity of silver nanoparticles by natural organic compounds extracted from cyperus sp. rhizomes

Synthesis and characterization Some of heterocyclic compounds from Nitrogen derivative

Biosynthesis, characterization and cytotoxicity of zinc nanoparticles using panax ginseng roots, araliaceae

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