Synthesis and characterization of novel xanthan gum-based pH-sensitive hydrogel for metformin hydrochloride release

Tushar,; Saraswat, Y. K.; Meena, Priyanka; Warkar, Sudhir G.

doi:10.1007/s00396-023-05135-9

Cited by 10 publications

(1 citation statement)

References 32 publications

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“…The dox release data in pH 7.4 and pH 1.2 were fitted in the various mathematical kinetic models such as First-order, Higuchi, and Korsmeyer-Peppas models [41] to understand the drug release mechanism. All the estimated parameters along with the coefficient of determination (R 2 ) are tabulated in Table 3.…”

Section: Kinetic Modeling Of Released Doxmentioning

confidence: 99%

A Silver Nanoparticle‐Embedded Tamarind Kernel Gum/Poly (Sodium Acrylate) Nanocomposite for Sustainable Release of Doxycycline

Rani,

Warkar,

Kumar

2024

ChemistrySelect

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The current work describes an eco‐friendly novel synthesis of silver (Ag) nanoparticles (NPs)/Tamarind kernel gum (TKG)/Poly (sodium acrylate) (PSA) nanocomposite without the use of any toxic materials. It is a one‐step route synthesis of silver nanocomposite hydrogel in which TKG and PSA are cross‐linked using methylene bisacrylamide (MBA) cross‐linker. The developed hydrogels were characterized using XRD, FTIR, UV‐visible, FE‐SEM, and TEM techniques. Doxycycline (dox) was chosen as a model drug for release studies using TKG/PSA and Ag/TKG/PSA nanocomposite. The observation is that Ag NP/TKG/PSA nanocomposite showed a pH‐dependent swelling which is higher at pH 7.4 than at pH 1.2. Similarly, the cumulative drug release percentage (CDR %) using silver nanocomposite is higher at pH 7.4 than at pH 1.2. Also, the presence of Ag NPs decreased the swelling ratio (SR) of TKG/PSA hydrogel, which controls the rate of release of the dox drug. In addition, the dox release kinetics were studied using the Korsmeyer‐Peppas and Higuchi model. It has been found that drug release data was fitted in the Korsmeyer‐Peppas model with a higher value of regression coefficient (R2). Thus, Ag/TKG/PSA nanocomposite showed satisfactory results for sustainable release of doxycycline drug.

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Section: Kinetic Modeling Of Released Doxmentioning

confidence: 99%

A Silver Nanoparticle‐Embedded Tamarind Kernel Gum/Poly (Sodium Acrylate) Nanocomposite for Sustainable Release of Doxycycline

Rani,

Warkar,

Kumar

2024

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Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Anshul,

Tomar,

Meena

et al. 2024

ChemistrySelect

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In this current study, hydrogels based on acacia gum (AG), polyacrylamide (PAM), and carboxymethyl tamarind kernel gum (CMTKG) were successfully developed and ciprofloxacin (drug) incorporated into it. To optimize the hydrogel, the concentrations of crosslinker and initiator were varied, and their effects on the swelling were examined. The hydrogel was subjected to characterization techniques such as Powder X‐ray Diffraction (PXRD), Scanning Electron Microscopy (SEM), Attenuated Total Reflection‐Fourier Transform Infrared spectroscopy (ATR‐FTIR), and Thermogravimetric analysis (TGA). The hydrogel swelling and in vitro drug release were assessed in pH 1.2 and 7.4 buffer solutions. The findings revealed that an alkaline pH yielded superior results for the swelling and in vitro drug release experiments compared to an acidic pH. The drug release kinetic of the ciprofloxacin‐loaded AG/PAM/CMTKG hydrogel followed the Korsmeyer–Peppas model, demonstrating non‐fickian diffusion at pH 7.4 and fickian mechanism at pH 1.2. The pH‐dependent behavior of ciprofloxacin‐loaded AG/PAM/CMTKG hydrogel displayed its potential implications for site‐specific ciprofloxacin release.

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Fabrication and evaluation of stimuli-sensitive xanthan gum-based hydrogel as a potential carrier for a hydrophobic drug ibuprofen

Meena,

Singh,

Warkar

2023

Colloid Polym Sci

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Synthesis and characterization of novel xanthan gum-based pH-sensitive hydrogel for metformin hydrochloride release

Cited by 10 publications

References 32 publications

A Silver Nanoparticle‐Embedded Tamarind Kernel Gum/Poly (Sodium Acrylate) Nanocomposite for Sustainable Release of Doxycycline

A Silver Nanoparticle‐Embedded Tamarind Kernel Gum/Poly (Sodium Acrylate) Nanocomposite for Sustainable Release of Doxycycline

Synthesis and Assessment of Acacia Gum‐Based Hydrogel as a Promising Novel Biopolymeric Matrix for Delivery of Ciprofloxacin

Fabrication and evaluation of stimuli-sensitive xanthan gum-based hydrogel as a potential carrier for a hydrophobic drug ibuprofen

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