Synthesis and Characterization of Novel Amphiphilic Polymers as Drug Delivery Nano Carriers

Pandey, Mukesh K.; Tyagi, Rahul; Gupta, Bhavna; Parmar, Virinder S.; Kumar, Jayant; Watterson, Arthur C.

doi:10.1080/10601320802380158

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…The detailed synthesis and characterization of polymer 2 has been published by us earlier (6). The number average molecular weight of the polymer 2 was in the range of 10,000-12,000 Da (PD 1.4), as determined by GPC.…”

Section: Resultsmentioning

confidence: 99%

Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

Gupta

Kumar

et al. 2011

Journal of Macromolecular Science, Part A

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Nano-particles with controllable particle size and shape are of great interest in biomedical applications (1). From the standpoint of drug carrier design with wide applicability to a variety of hydrophobic drugs, an effective strategy would be to prepare a simple copolymer having the property to form stable polymeric micelles which can entrap hydrophobic drugs in the core (2). In this study, we have attached saturated and unsaturated long chain acid chlorides to the copolymer of PEG and dimethyl-5-aminoisophthalate via an amide linkage in order to make the copolymers amphiphilic. Further, bioactive compounds like β-carotene, which has considerable double bond unsaturation and curcumin, which has considerable aromatic unsaturation, were encapsulated in these amphiphilic copolymers which successfully demonstrated their drug loading ability.

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Section: Resultsmentioning

confidence: 99%

Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

Gupta

Kumar

et al. 2011

Journal of Macromolecular Science, Part A

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“…We have also reported the synthesis of and PEG based polymers with dimethyl isophthalate and different diacids as linker for encapsulation of β-cyfluthrin and imidacloprid, respectively (16,17). There are also reports where the nano-spheres formed by the amphiphilic polymers were found to carry sufficient amount of drug, such as aspirin (18).…”

Section: Introductionmentioning

confidence: 95%

Synthesis and Characterization of Novel Poly(ethylene glycol) Based Amphiphilic Polymers

Kaushik

Shakil

Kumar

et al. 2012

Journal of Macromolecular Science, Part A

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The formation of micelles in a solvent that is selective for one of the blocks is one of the most important and useful properties of block copolymers. In the present study, polymerization reaction between the monomers, dimethyl 5-hydroxyisophthalate and poly(ethylene glycols) of different molecular weights viz. 600, 1000, 1500 and 2000 has been carried out in solventless condition at 80-90 • C. The resulting polymers, were derivatized by attaching dodecanyl chain to phenolic hydroxyl group. These novel functionalized amphiphilic polymers have been characterized by 1 H and 13 C NMR spectroscopy. These polymers, when dissolved in water, aggregate to form micelles, whose sizes were determined using Dynamic Light Scattering (DLS) which ranged from 29.21 to 62.9 nm.

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“…88 The polymers synthesized from 5-aminoisophthalate possessing an aminoacyl chain demonstrated better drug loading capacity for a wide variety of bioactive compounds than the previously reported polymers carrying acyloxy chains (Scheme 10). 90 The copolymers 50-56 were evaluated for their drug encapsulation capacity using curcumin, a bio-active naturally occurring compound of current interest in chemical and biological research worldwide. The synthesized polymers having long alkyl chains attached via an ether linkage, viz.…”

Section: Biocatalytic Synthesis Of Peg-based Drug Delivery Systemsmentioning

confidence: 99%

Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

et al. 2016

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Synthesis and Characterization of Novel Amphiphilic Polymers as Drug Delivery Nano Carriers

Cited by 14 publications

References 6 publications

Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

Amphiphilic Copolymers having Saturated and Unsaturated Aliphatic Side Chains as Nano Carriers for Drug Delivery Applications

Synthesis and Characterization of Novel Poly(ethylene glycol) Based Amphiphilic Polymers

Synthesis of macromolecular systems via lipase catalyzed biocatalytic reactions: applications and future perspectives

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