Synthesis and characterization of PEGylated derivatives of rosin for sustained drug delivery

Nande, Vishwanath S.; Barabde, Umesh V; Morkhade, Dinesh M.; Patil, Arun T.; Joshi, S. B.

doi:10.1016/j.reactfunctpolym.2006.03.021

Cited by 45 publications

(46 citation statements)

References 14 publications

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“…From this result it can suggest than melting point of derivative was affected from rosin content and melting point of PEG. This result shows consistent with previous study [4], [14], [19]. C-NMR spectra of rosin-PEG 1500 derivatives.…”

Section: International Journal Of Chemical Engineering Andsupporting

confidence: 94%

“…They are monocarboxylic acids of alkylated hydrophenanthrene; abietic acid constitutes the principal resin acid. [3], [4]. It is soluble in alcohol, ether, benzene and chloroform but insoluble in water Polyethylene glycol (PEG) or poly (ethylene oxide) is petroleum base polymer represent water-soluble mono hydroxy alcohols.…”

Section: Introductionmentioning

confidence: 99%

“…It is soluble in alcohol, ether, benzene and chloroform but insoluble in water Polyethylene glycol (PEG) or poly (ethylene oxide) is petroleum base polymer represent water-soluble mono hydroxy alcohols. These are water-soluble polymers used as base in ointments and suppositories, as plasticizer in film coating, as auxiliary emulsifiers [4] industrial [5], [6], etc. In the previous study, modification of rosin also improves its safety and stability.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Kanlaya¹,

Sumrit²,

Amorn³

2016

IJCEA

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Abstract-This research aims to synthesize and characterize of rosin-polyethylene glycol derivatives from natural rosin and polyethylene glycol 1500 (PEG1500). In this research, reaction conditions for the synthesis of rosin-PEG derivatives such as catalyst type, catalyst concentration, reaction temperature and etc. were optimized. Chemical and physical properties of water soluble rosin (WSR) were characterized using FT-IR, 13 C-NMR, DSC, and GPC. It was found that water soluble rosin-PEG derivatives were successful synthesized from natural china rosin and PEG using 2% ZnO as catalyst, 2:1 molar ratio of rosin: PEG at 250 O C for 9 hours. The obtained rosin-PEG1500 derivative were completely soluble in water and rosin-PEG1500 derivative showed melting point at 40.6Index Terms-Water soluble rosin, polyethylene glycol 1500, esterification, zinc oxide.

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Section: International Journal Of Chemical Engineering Andsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Kanlaya¹,

Sumrit²,

Amorn³

2016

IJCEA

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“…2. The differences in the behavior of PD-1 and PD-2 films in the probe media are related to their composition; PD-2 contain higher concentration of newly formed esters (17). Presence of more free acids in the derivative resulted in formation of soluble salts that dissolve in the probe media.…”

Section: Water Uptake and Weight Lossmentioning

confidence: 99%

“…These derivatives were characterized for their physico-chemical properties like molecular weight, acid number, solubility, glass transition temperature, film-forming property etc. (17).…”

Section: Introductionmentioning

confidence: 99%

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

et al. 2008

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Abstract. The purpose of the present study was to investigate the potential use of two PEGylated derivatives of rosin (PD) as sustained release film forming materials. The derivatives differed chemically by their acid numbers-PD-1 with 120.93 and PD-2 with 88.19. The derivative films were characterized for surface morphology, water uptake-weight loss, angle of contact, water vapor transmission rate, mechanical properties and permeability study. Dissolution of diclofenac sodium (DS) and propranolol hydrochloride (PHL) as model drugs was studied from coated pellets. The films of derivatives with and without plasticizers were smooth and continuous. PD-2 films developed greater numbers of pores when in contact with phosphate buffer pH 6.8. The low weight loss, low angles of contact and high water vapor transmission rate of PD-2 films were related to presence of higher concentration of PEG esters. Higher tensile strength and percent elongation of PD-2 films was due to greater degree of internal plasticization of the derivative. The permeability of films to model drugs propranolol hydrochloride and diclofenac sodium was inversely proportional to the film thickness and dibutyl phthalate concentration in them; the permeability being greatest in PD-2 films containing 10% PEG 200. Dissolution rate of propranolol hydrochloride was higher from the coated pellets. The dissolution data followed zero order, Baker-Lonsdale equation and Hixon-Crowell equation of release kinetics with high correlation coefficients. The mechanism of drug release from these coated systems however followed class II transport (n>1.0). The derivatives investigated could successfully retard release of the model drugs and offers an alternative to the conventionally used polymers.

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Preparation and UV‐curing properties of rosin‐based allyl phthalate oligomer

Luo

Bai

Zhou

et al. 2023

Polymers for Advanced Techs

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The acid–base stability of UV cured materials is an important issue in the field of material applications. Bio‐based rosin modified diallyl phthalate oligomers (RS‐DAP) with higher hydrophobicity were synthesized by the radical reaction of rosin with diallyl phthalate. The structures of RS‐DAP were confirmed by FT‐IR, 1H NMR and electrospray ionization high resolution mass spectrometry (ESI‐HRMS). The UV‐curing properties of acrylate components containing RS‐DAP were investigated by FT‐ATR. And the effects of RS‐DAP dosage on the double bond conversion of neopentyl glycol diacrylate (NPGDA) and the properties of cured film were evaluated. The results show that the introduction of aromatic rings of DAP and the rigid structure of rosin moiety can improve the UV curing rate, gelation ratio, hardness, and chemical resistance of cured film. The composition of RS‐DAP resin with acrylate monomer and RJ313 resin can be 3D printed into specimen with smooth surface, good precision, good thermal stability, hardness of 6 H, and 93% of gel content.

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Synthesis and characterization of PEGylated derivatives of rosin for sustained drug delivery

Cited by 45 publications

References 14 publications

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Synthesis and Characterization of Water Soluble Rosin-Polyethylene Glycol 1500 Derivative

Investigation of PEGylated Derivatives of Rosin as Sustained Release Film Formers

Preparation and UV‐curing properties of rosin‐based allyl phthalate oligomer

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