Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels

Dobić, Sava N.; Filipović, Jovanka M.; Tomić, Simonida Lj.

doi:10.1016/j.cej.2011.10.083

Cited by 63 publications

(30 citation statements)

References 30 publications

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“…The results found here are in accordance with those found by Tomić and Filipović [8]. Their complexes prepared with PEG/PIA showed good adhesive capacity when they tested them by measuring the force needed to break the contact established between discs of the complex and polypropylene plates.…”

Section: Measurement Of Adhesion Strengthsupporting

confidence: 93%

“…With the increase of pH, the material swelled and subsequently eroded. Dobić and coworkers [8] have prepared matrices of hydroxyethyl methacrylate (HEMA), poly(ethylene glycol) dimethacrylate (PEGDMA) and IA which showed typical behavior of anionic hydrogels. They swelled in response to the increase of pH and temperature of the medium.…”

Section: Swelling Testmentioning

confidence: 99%

“…Its excellent properties make it ideal for use in drug delivery applications, as well as in cell delivery vehicles for promoting tissue regeneration [8].…”

Section: Introductionmentioning

confidence: 99%

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Self-crosslinkable complexes based on poly(ethylene glycol) (PEG), poly(itaconic acid) (PIA) and N-methylol acrylamide (NMA) as pharmaceutical hydrophilic matrices

et al. 2015

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The formation and characterization of poly(itaconic acid)/N-methylol acrylamide/poly(ethylene glycol) (PIA/NMA/PEG) complexes through in situ polymerization of itaconic acid on poly(ethylene glycol) was investigated. FTIR indicated that PEG crystallization was hindered by complex formation. The decrease in the crystallinity of PEG was also observed by DSC and indicated that the mobility of some PEG segments was inhibited by the presence of the polyacid. According to the swelling experiments, complexes proved to be suitable for use as excipient in the preparation of drug delivery systems responsive to pH changing. DMA was used to estimate the crosslink densities and the results were found to be in good agreement with the swelling results. Further, the adhesion strength of the synthesized polymers was used as preliminary evaluation of their potential of mucoadhesion. The results indicated that the adhesion performance is related to the presence of NMA. Drugs which suffer degradation in stomach pH, such as proteins and enzymes are potential candidates to be included in the systems based on PIA/ NMA/PEG to pass through the stomach (pH near to 1.2-3.5). Upon reaching the initial portion of the small intestine (pH [5.5), the polymer will swell and release the active substance via diffusion and/or erosion of the matrix.

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Section: Measurement Of Adhesion Strengthsupporting

confidence: 93%

Section: Swelling Testmentioning

confidence: 99%

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Self-crosslinkable complexes based on poly(ethylene glycol) (PEG), poly(itaconic acid) (PIA) and N-methylol acrylamide (NMA) as pharmaceutical hydrophilic matrices

et al. 2015

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“…Hydrophilic polymers based on PHEMA are suitable for biomedical engineering applications because of their properties such as: high water content, non-toxicity, softness, flexibility and good compatibility with skin and human tissue and also easy modification of these properties via chemical formulation (Zhu and Marchant, 2011;Dobic et al, 2012). PHEMA-based materials are widely used in ophthalomology-contact lenses and orbital implants (Allan, 1999;Lloyd et al, 2001).…”

Section: Poly (2-hydroxyethyl Methacrylate) (Phema) Nanoparticlesmentioning

confidence: 99%

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets

Aras

Khokhar²,

Qureshi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…[29][30][31][32] Recently, LAA has been reported to hasten wound repair and regeneration in the excision wounds of mice exposed to γ-radiation. [32][33][34][35] A series of articles have been published by many authors who synthesized novel hydrogel from copolymers for instance, N-vinyl-2-pryrrolidone and mono-, di-, triprotic acids such as acrylic, itaconic, and tartaric acid. [35][36][37] This track was adapted to open a new gate of novel hydrogels to be utilized in a wide range of fields.…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of poly(acrylamide)-incorporated poly(L-ascorbic acid) hydrogels in controlled release and wound dressings

Awadallah‐F

2013

Designed Monomers and Polymers

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In this study, hydrogel specimens were synthesized by acrylamide (AAm) implying different quantities of L-ascorbic acid (LAA) vis-à-vis γ-rays radiation technique. The prepared gels were characterized by various techniques. Fix's theory was applied to poly(acrylamide) (P(AAm)/LAA) hydrogels and diffusion coefficients were evaluated. Hardness, water vapor transmission rate, tensile strength, and degree of adhesiveness were preformed on gel systems. The outcome results indicate that the hydrogel specimens are conveniently utilized in wound dressings as the first application. The second application of this gel system is drug release of anti-fungal terbinafine hydrochloride (TER-HCl), which was used in skin wound healings. Adsorption and release of TER-HCl to and fro from P(AAm/LAA) hydrogel specimens were examined. The impact of PLAA quantities into the gelling specimens on the adsorption capacities and the impact of pH on the releasing behavior of TER-HCl were investigated. The results showed the TER-HCl adsorption capacities of hydrogels are found to rise up from 9.5 ± 0.22 to 99 ± 0.18 mg TER-HCl per g dry gel, dependent on the gradient increment in quantity of PLAA in the gel structures. The results of in vitro TER-HCl release in different buffer solutions revealed that the paramount parameters affecting the drug release behavior of gel systems are pH of surrounding media and quantity of PLAA inside. In sum up, the prepared hydrogels have synergistic effect and they may be utilized in wound dressing and TER-HCl drug release of skin wound healings applications as well.

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Synthesis and characterization of poly(2-hydroxyethyl methacrylate/itaconic acid/poly(ethylene glycol) dimethacrylate) hydrogels

Cited by 63 publications

References 30 publications

Self-crosslinkable complexes based on poly(ethylene glycol) (PEG), poly(itaconic acid) (PIA) and N-methylol acrylamide (NMA) as pharmaceutical hydrophilic matrices

Self-crosslinkable complexes based on poly(ethylene glycol) (PEG), poly(itaconic acid) (PIA) and N-methylol acrylamide (NMA) as pharmaceutical hydrophilic matrices

Targeting Cancer with Nano-Bullets: Curcumin, EGCG, Resveratrol and Quercetin on Flying Carpets

Synergistic effect of poly(acrylamide)-incorporated poly(L-ascorbic acid) hydrogels in controlled release and wound dressings

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