Synthesis and characterization of poly(N-isopropyl methacrylamide) core/shell nanogels for controlled release of chemotherapeutics

Peters, Jonathan T.; Hutchinson, Sarah; Lizana, Nisha; Verma, Isha; Peppas, Nicholas A.

doi:10.1016/j.cej.2018.01.009

Cited by 32 publications

(12 citation statements)

References 20 publications

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“…Hard nanoparticles can be fabricated from materials such as silica, gold, quantum dots, carbon nanotubes, graphene sheets, and polymeric nanoparticles. Whereas soft nanoparticles with mechanical properties comparable to natural hydrogels include liposomes, dendrimers, polymeric micelles, and nanogels …”

Section: Nanofunctionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

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110

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Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.

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Section: Nanofunctionalized Hydrogelsmentioning

confidence: 99%

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Elkhoury

Russell

Sánchez-González

et al. 2019

Adv Healthcare Materials

Self Cite

110

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“…Temperature‐ and redox‐responsive nanogels generally involve a redox‐responsive cross‐linker and temperature‐responsive polymer matrix. Some of the examples of temperature‐responsive polymers are poly( N ‐isopropylacrylamide) (PNIPAAm), poly ( N , N ′‐diethyl acrylamide), poly( N ‐( l )‐(1‐hydroxymethyl)propyl methacrylamide), and poly(oligo(ethylene oxide)monomethyl ether methacrylate) (POEOMA) . Tian et al fabricated redox‐ and thermo‐responsive nanogels by precipitation copolymerization of OEOMA, 2‐(2‐methoxyethoxy)ethyl methacrylate, and disulfide cross‐linker BAC.…”

Section: Dual and Triple Stimuli‐responsive Nanogelsmentioning

confidence: 99%

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Kumar

Liu

Behl

2019

Macromolecular Bioscience

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Increasing recognition of the role of oxidative stress in the pathogenesis of many clinical conditions and the existence of defined redox potential in healthy tissues has led to extensive research in the development of redox‐responsive materials for biomedical applications. Especially, considerable growth has been seen in the fabrication of polymeric nanogel–based drug delivery carriers utilizing redox‐responsive cross‐linkers bearing a variety of functional groups via various synthetic strategies. Redox‐responsive polymeric nanogels provide an advantage of facile chemical modification post synthesis and exhibit a remarkable response to biological redox stimuli. Due to the interdisciplinary nature of the subject, a more profound combined conceptual knowledge from a chemical and biological point of view is imperative for the rational design of redox‐responsive nanogels. The present review provides an insight into the design and fabrication of redox‐responsive nanogels with particular emphasis on synthetic strategies utilized for the development of redox‐responsive cross‐linkers, polymerization techniques being followed for nanogel development and biomedical applications. Cooperative effect of redox trigger with other stimuli such as pH and temperature in the evolution of dual and triple stimuli‐responsive nanogels is also discussed.

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“…It instantly exhibited hydrophilic and hydrophobic behaviors when the environmental temperature was below and above its LCST, respectively . Many researches have taken advantages of abrupt changes of PNIPAAm in various applications, such as metal ion chelation, controlled drug release, cell uptake, and enhanced enzyme activity …”

Section: Introductionmentioning

confidence: 99%

Water dispersible magnetite nanocluster coated with thermo‐responsive thiolactone‐containing copolymer

Paenkaew

Kajornprai

Rutnakornpituk

2020

Polymers for Advanced Techs

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This work focused on surface modification of magnetite nanoparticle (MNP) with poly(poly(ethylene glycol) monomethyl ether methacylate)-b-(poly(N-isopropylacrylamide)-st-poly(thiolactone acrylamide)), PPEGMA-b-(PNIPAAm-st-PTlaAm), diblock copolymer, synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization to obtain the particles having good water dispersible PPEGMA brushes, thermo-responsive PNIPAAm, and reactive thiolactone groups of PTlaAm.The thiolactone moiety in the copolymer can readily react with amino groups grafted on MNP surface and essentially induced the formation of MNP nanocluster.According to transmission electron microscopy (TEM), the size of the nanocluster ranged between 200 and 500 nm per cluster with 8 to 10 nm in diameter for each particle. Hydrodynamic diameter of the nanocluster significantly decreased as the dispersion temperature increased from 25 C to 45 C due to the shrinkage of thermo-responsive PNIPAAm when crossing its lower critical solution temperature (LCST). This stable nanocluster might be potentially used as a magnetic carrier for control release of entrapped entities with a thermally triggering mechanism. K E Y W O R D S magnetite, nanocluster, thermo-responsive, thiolactone, water dispersible

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Synthesis and characterization of poly(N-isopropyl methacrylamide) core/shell nanogels for controlled release of chemotherapeutics

Cited by 32 publications

References 20 publications

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

Soft‐Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications

A Comprehensive Outlook of Synthetic Strategies and Applications of Redox‐Responsive Nanogels in Drug Delivery

Water dispersible magnetite nanocluster coated with thermo‐responsive thiolactone‐containing copolymer

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