Synthesis and characterization of polysaccharide-maghemite composite nanoparticles and their antibacterial properties

Abstract

The aim of this study was to obtain saccharide (dextran and sucrose)-coated maghemite nanoparticles with antibacterial activity. The polysaccharide-coated maghemite nanoparticles were synthesized by an adapted coprecipitation method. X-ray diffraction (XRD) studies demonstrate that the obtained polysaccharide-coated maghemite nanoparticles can be indexed into the spinel cubic lattice with a lattice parameter of 8.35 Å. The refinement of XRD spectra indicated that no other phases except the maghemite are detectable. The characterization of the polysaccharide-coated maghemite nanoparticles by various techniques is described. The antibacterial activity of these polysaccharide-coated maghemite nanoparticles (NPs) was tested against Pseudomonas aeruginosa 1397, Enterococcus faecalis ATCC 29212, Candida krusei 963, and Escherichia coli ATCC 25922 and was found to be dependent on the polysaccharide type. The antibacterial activity of dextran-coated maghemite was significantly higher than that of sucrose-coated maghemite. The antibacterial studies showed the potential of dextran-coated iron oxide NPs to be used in a wide range of medical infections.

Magnetite Nanostructures as Novel Strategies for Anti-Infectious Therapy

“…Dextran and sucrose coated MNPs (with diameter of 5.8 and 7.3 nm respectively) showed good inhibition against E. coli ATCC 25922 strain, especially at concentrations between 0.01-0.625 mg/mL [41]. This study also revealed that dextran is more effective as a coating medium regarding bactericidal activity compared to sucrose.…”

“…Other recent study reports the modulation of C. krusei infections by MNPs [18]. This modulation is dependent by the surface of MNPs and the authors pointed out that microbial interactions are influenced by interfacial forces, such as the electrostatic field, that plays a significant role on the interaction between MNPs and microbial surfaces [41].…”

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

“…The amount of iron was determined using potassium dichromate (K 2 Cr 2 O 7 ). The Fe 2+ was titrated potentiometrically in agreement with previous studies [24]. After the last separation by centrifugation, the particles were dispersed into dextran (30% w/v).…”

Selective formation of iron oxide and oxyhydroxide nanoparticles at room temperature: Critical role of concentration of ferric nitrate

“…The preparation of phase pure iron oxide or oxyhydroxide is a challenging task as their formation depends on various parameters such as concentration of iron starting material, pH and temperature of the solution. Previous attempts to prepare phase pure iron oxides or oxyhydroxides has resulted in the formation of product(s) such as maghemite (g-Fe 2 O 3 ) [21,22], lepidocrocite (g-FeOOH) [23], goethite (a-FeOOH) [24e26], akaganeite (b-FeOOH) [27], magnetite (Fe 3 O 4 ) [28,29] and hematite(a-…”