Synthesis and Characterization of some new β-Lactam Derivatives from Azo Sulphadiazine and its Biological Evaluation as Anticancer

Khdur, Radhiyah A.; Zimam, Ezzat H.

doi:10.13005/ojc/340140

Cited by 14 publications

(2 citation statements)

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“…After the incubation period, each plate was observed and the inhibition zone was measured by the ruler; this was repeated three times for each concentration. The minimum inhibitory concentration (MIC) of Ligand (HL) and its complexes were determined according to [22] represented by the last concentration with little or no visible growth.…”

Section: B-antibacterial Activity Of Ligand (Hl) and Its Complexes On The Isolation Bacteriamentioning

confidence: 99%

Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

2021

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The reaction of 6-amino pencillanic acid with Schiff base "(Z)-3-((3-hydroxybenzylidene) amino) phenol)" has formed a novel Azo-azomethine ligand (HL) "( 7-((Z)-(2-hydroxy-4-((Z)-((3-hydroxyphenyl) imino) methyl) phenyl) diazenyl)-3, 3dimethyl-6-oxo-2-thiabicyclo [3.2.0] heptane-4-carboxylic acid". The ligand (HL) is characterized by 1 H-NMR, 13 C-NMR, Mass Spectrometry, CHNs, Uv-Visible, and FT-IR. This new Ligand (HL) is used to prepare numerous complexes using transition metal ions Fe (II) Cu (II), and Ni (II). These complexes' properties are studied using different techniques such as Mass Spectroscopy, Atomic Absorption, FT-IR, UV-Visible, Magnetic Moment, and Molars Conductivity. All these techniques indicate 1:2 (M: L) stoichiometry's synthesized complexes. Azo-azomethine ligand (HL) acts as a tridentate ligand to form the octahedral shape complexes with sp 3 d 2 , d 2 sp 3 hybridization. These new ligands and complexes are studied for their biological activity. The results show that the minimum inhibition concentration (MIC) of the prepared compounds has inhibition activity against Staphylococcus aureus bacteria and obviously affects the ability of pathogenic bacteria (S. aureus) to attain virulence factors such as Biofilm and hemolysin toxin

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Section: B-antibacterial Activity Of Ligand (Hl) and Its Complexes On The Isolation Bacteriamentioning

confidence: 99%

Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

2021

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“…Sulfadiazine is one of the antibiotic drugs that belong to the sulfonamide group; it has been utilized in veterinary and human therapy over 60 years [1]. Also, it is utilized for the treatment of urinary tract infections (UTIs) [2], and in clinic as a topical agent either alone or in combination with other compounds in the treatment of wound and burn infections [3]. Thiazoles are a group of heterocyclic compounds that possess a wide variety of biological activities and their utility as medicaments is very much established [4].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Some New Barbituric Acid Derivatives Containing Thiazole Moiety from Sulfadiazine

Fahad¹,

Zimam²,

Mohamad³

2019

Nano BioMed ENG

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A new series of barbituric acid derivatives w prepared and characterized by Fourier-transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H-NMR) and nuclear magnetic resonance ( 13 C-NMR). The antimicrobial studies of synthesized compounds were screened for antibacterial activity against three different types of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli), and against two types of fungi (Candida albicans and Aspergillus flavus). In this research, a reaction of sulfadiazine with chloroacetylchloride gave 2-chloro-N-(4-(N-pyrimidin-2-ylsulfamoyl) phenyl) acetamide [A] which was reacted with thiourea, and with K 2 CO 3 to give thiazole derivative [B]. The last compound (thiaole derivative) was reacted with chloroacetyl chloride in basic medium to form compound [R]. 5,5-Diethyl barbituric acid and 5-phenyl,5-ethyl barbituric acid were treated with formaldehyde to give 1,3-bis(hydroxyl methyl)barbituric acids derivatives [B 1 ] and [B 2 ]. Finally, the compound [R] reacted with 1,3-bis(hydroxyl methyl) barbituric acids derivatives via Williamson reaction to form new barbituric acid derivatives [RB 1 ]and [RB 2 ]. By the reaction of 5,5-diethyl barbituric acid with 5-phenyl,5-ethyl barbituric acid, new compounds of barbituric acids derivatives [RB 3 ] and [RB 4 ] were obtained. The biological applications of the synthesized compounds showed a greater effect in antimicrobial activities from the starting material (sulfadiazine).

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RETRACTED ARTICLE: Synthesis and characterization of new compounds derived from 1H-indol-5-ylamine

AL-Suraify

Hussien

2022

Appl Nanosci

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Synthesis and Characterization of some new β-Lactam Derivatives from Azo Sulphadiazine and its Biological Evaluation as Anticancer

Cited by 14 publications

References 0 publications

Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

Preparation, Characterization, and Study of Complexes Containing Beta-lactam Group with Some Transitional Elements and their Biological Activity

Synthesis and Antimicrobial Activity of Some New Barbituric Acid Derivatives Containing Thiazole Moiety from Sulfadiazine

RETRACTED ARTICLE: Synthesis and characterization of new compounds derived from 1H-indol-5-ylamine

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