Synthesis and chemiluminescence of 1,3-disubstituted pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyridazine-5,8(6h,7h)-diones and related compounds

Recent developments in aminopyrazole chemistry

“…The reaction of 5-aminopyrazole-4-carbonitriles 140 with dimethyl acetylenedicarboxylate (DMAD) in DMSO in the presence of potassium carbonate gave pyrazolo [3,4-b]pyridine-5,6-dicarboxylates 234 in 14-53% yields 133 (Scheme 64). …”

Chemiluminescent Detection with Horseradish Peroxidase and Luminol

“…Under normal conditions, 7 -dimethylamino-naphthalene-1,2-dicarbonic acid hydrazide (see Figure 1) gives a better quantum yield than does luminol (Allen, 1982;Gundermann, 1965). Improvement has also been published in using DBPH (4-(5,6-dimethoxy-2-benzothiazolyl) phthalylhydrazide) or, e.g., substituted 4-amino-pyrazolo-pyrido-pyridazine-dione derivatives (Tominaga et al, 1995).…”

Synthesis and characterization of some pyrazole derivatives of 1,5‐diphenyl‐1H‐pyrazole‐3,4‐dicarboxylic acid

“…The chemistry of pyrazole derivatives have been the subject of much research because of their importance in various applications and their widespread potential biological and pharmacological activities such as antimicrobial, antiviral, antitumor, anti‐inflammatory, pesticidal, antifungal, antidepressant, antipyretic, and analgesic [1–10]. Thus, these compounds have been the focus of high attention among medicinal chemists [11–16]. It is also known that biological activities of pyrazole derivatives which include substituted heteroaryl groups increase and that some pyrazolo‐pyridazine compounds which include the same heteroaryl groups are used as a cure for many diseases [17–25].…”