2002
DOI: 10.1002/1522-2675(200211)85:11<3624::aid-hlca3624>3.0.co;2-y
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Synthesis and Crystal Structure of Peptide-2,2′-Biphenyl Hybrids

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Cited by 24 publications
(19 citation statements)
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“…This last family of compounds (D) presents interesting characteristics, including dynamical properties in solution [44], ordered structures in the solid phase [45], and biological activity as calpain inhibitors [46,47]. Some of these properties arise from the presence of amino acid residues as well as aromatic rings able to participate in a variety of non-covalent bonds, including hydrogen bonds [48] and arene interactions [49].…”
Section: Introductionmentioning
confidence: 98%
“…This last family of compounds (D) presents interesting characteristics, including dynamical properties in solution [44], ordered structures in the solid phase [45], and biological activity as calpain inhibitors [46,47]. Some of these properties arise from the presence of amino acid residues as well as aromatic rings able to participate in a variety of non-covalent bonds, including hydrogen bonds [48] and arene interactions [49].…”
Section: Introductionmentioning
confidence: 98%
“…Additionally, the crystal structure of 4a as shown in Scheme 1 showed that the p-phenyl ring has about 50 degree from the planarity with the aniline ring. This twisting for unsubstituted biphenyl compounds was also observed before by other groups [33][34][35]. This observed twisting could explain a 3/2 mixture of rotamers obtained for compound 4b, in which the naphthyl group acts like an o-methyl on phenyl, which cannot rotate past the o-nitrile of the aniline ring.…”
Section: Resultsmentioning
confidence: 99%
“…are derivatives of 1,1-biphenyl with amino acids or peptide chains at the positions C2 and C2 0 (Mann et al, 2002;Montero, Mann et al, 2004) have been studied intensively to overcome the disadvantages mentioned above.…”
Section: Chemical Contextmentioning
confidence: 99%