Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines

Utility of thieno[2,3-b] pyridine derivatives in the synthesis of some condensed heterocyclic compounds with expected biological activity

“…The aforementioned biological activities stimulated our interest for the synthesis of several new condensed heterocyclic compounds containing thieno [2,3-b] pyridine moiety condensed with each of pyridine, cyclopentyl, tetrahydroquinoline, pyrimidine, 1,6-naphthiridin, benzofuro [2,3-b] pyridine, imidazo [1,2-c] pyrimidine, [1,2,3] triazolo [1,5-a] pyrimidine. The new condensed heterocyclic derivatives possessing latent functional substituents appear promising to fulfill the objectives of our biological activity studies and the desired chemical transformations.…”

“…The thieno [2,3-b]pyridine derivatives occupy special place and have attracted considerable attention because of their broad pharmacological activities, including anticancer [1][2][3][4][5][6][7][8][9], antiviral [10][11][12][13], anti-inflammatory [14][15][16][17], antimicrobial [18,19], antidiabetic [20][21][22][23], antihypertensive [24][25][26] and osteogenic [27,28] activities, in addition to treatment of CNS disorders [29][30][31].…”

Research Progress on Application of Organic Diamines and Their Derivatives

“…5,6-heteroaromatically annulated pyridine-2,4-diamines have been evaluated against six human cancer cell lines in vitro and it was showed that benzo[g] annulated pyrido [2,3-b]indolediamines had relatively high cytotoxic activity [38] .…”

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety

“…The thieno [2,3-b]pyridine derivatives occupy special place and have attracted considerable attention because of their broad pharmacological activities, including anticancer [1][2][3][4][5][6][7][8][9], antiviral [10][11][12][13], anti-inflammatory [14][15][16][17], antimicrobial [18,19], antidiabetic [20][21][22][23], antihypertensive [24][25][26] and osteogenic [27,28] activities, in addition to treatment of CNS disorders [29][30][31]. Also, pyridine derivatives of different heterocyclic nucleus have shown potent pharmacological properties like antifungal [32,33], antitubercular [34], antibacterial [35], antimicrobial [36], insecticida [37].…”