Synthesis and in vitro Anti-inflammatory Activity of Some 2-(Methylsulphonyl Amino)- 4-(Arylthio)methyl Thiazoles

Waghmare, Rahul A.; Lingampalle, Dinesh L.; Jagrut, Vasant B.; Asrondkar, Ashish

doi:10.14233/ajomc.2018.ajomc-p92

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NSNS-AIDs are nonselective inhibitors of the enzymes which are responsible for the conversion of arachidonic acid to prostaglandins (Waghmare et al, 2017). These medications have unfavourable effects on the digestive system, including dyspepsia, gastroduodenal ulcers, gastritis and bleeding (Khan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Evaluation of Anti-Inflammatory Activity of Newly Synthesized 1,3,4 Oxadiazole Derivatives

K.¹,

Neelakandeswari²,

P.³

et al. 2022

IJZI

View full text Add to dashboard Cite

In the area of heterocyclic chemistry, oxadiazole has made major contributions. An enormous number of oxadiazoles have been synthesized and exposed to biological screening; the screening results improved their status due to its potential activities and their efficacy in diverse fields of daily life. Due to its wide range of pharmacological and therapeutic effects, the 1,3,4-oxadiazole moiety is the most important oxadiazole. In this study, we discuss a new family of 2,5-disubstituted 1,3,4-oxadiazole compounds' anti-inflammatory characteristics (4a-4h).The antiinflammatory efficacy of the oxadiazole derivative was studied by utilizing Human Red Blood Cell membrane stabilization (HRBCs) method. Many synthesized compounds displayed remarkable anti-inflammatory activity in HRBCs test. In the novel synthesized derivatives, compounds 2-(5-bromo-2-(trifluoromethoxy)phenyl)-5-p-tolyl1,3,4-oxadiazole (4h) and 2-(5-bromo-2-(trifluoromethoxy) phenyl)-5-phenyl-1,3,4-oxadiazole (4a) exhibited the maximum activity of 90.76 % and 88.35 % protection, respectively at concentration 500 µg/ml, compared with DFS that showed 91.86 % inhibition of RBC haemolysis at the same concentration.

show abstract

Section: Introductionmentioning

confidence: 99%