Synthesis and <i>In Vitro</i> Evaluation of C-methylcalix[4]resorcinaryl octacinnamate and C-methylcalix[4]resorcinaryl octabenzoate as the Sunscreen

Abstract

The present study was aimed to synthesize and evaluate sunscreen activity of C-methylcalix [4]resorcinaryl octacinnamate and C-methylcalix[4] ABSTRAK Studi ini dimaksudkan untuk mensintesis dan menguji aktivitas tabir surya senyawa C-metilkaliks[4]resorsinaril oktasinamat dan C-metilkaliks[4]resorsinaril oktabenzoat. Senyawa target disintesis melalui dua tahap reaksi yaitu sintesis C-metilkaliks[4]resorsinarena melalui reaksi kondensasi resorsinol dan asetaldehida menggunakan katalis

Synthesis and Test of C-Phenylcolics [4] Resorcinilate Octabenzoat Sunblock Activity

“…The strength of the activity of a material or sunblock product can be seen from the SPF value. The SPF value can be determined from the UV spectrum using the formula; SPF = 10A (average) where A is the absorption value in the wavelength range of 280 nm-320 nm (Ngurah et al, 2017). The results of the calculation of the SPF Cmethylcallic value [4] of resorcinyl octabenzoate are 30, and this value is in accordance with the requirements required by the American Academy of Dermatology.…”

“…This compound has good stability to temperature (does not melt to 400 °C), so that when coupled with a benzoyl group that has the character of a sunblock compound, it will be obtained by the compound resixcinarene calix [4] derivatives which have stable properties while having good activity as UV radiation absorbent (Ngurah et al, 2014). One compound of cervical [4] resorcinarene which has good sunblock activity is C-methyl calix [4] resorcinyl octinamic (Ngurah et al, 2017).…”

Synthesis, Sunscreen, and Toxicity <i>In Vitro</i> Test of C-Styrylcalix[4]resorcinaryl Octacinnamate and C-Phenylcalix[4]resorcinaryl Dodecacinnamate

“…The structural modifications or preparation of analog compounds are mostly investigated since they are cheaper and faster to carry out. The in vitro assay can be carried out through the ultraviolet spectrometry method and can also use the human skin fibroblast cell cultures [11,[15][16]. Meanwhile, to test the level of safety against the human body, it is carried out in vivo.…”

“…The in vitro SPF value was determined using Eq. ( 1), a method used by Ngurah et al [15]. The absorbance of the sample was determined at 5 nm intervals in the length range of 290-320 nm.…”