Synthesis and Pharmacological Activity of 3‐(Aroyl)‐ and 3‐(Hetaroyl)imidazo[1,2‐a]benzimidazoles.

Abstract

Synthesis and Pharmacological Activity of 3-(Aroyl)-and 3-(Hetaroyl)imidazo[1,2-a]benzimidazoles. -Among the novel 3-(het)arylimidazobenzimidazoles (III) and (VI) prepared, derivatives with a wide variety of biological activities, including membrane-stabilizing, antiaggregating, hypoglycemic, hyperglycemic or spasmolytic activity, are identified. -(ANISIMOVA, V. A.; SPASOV, A. A.; OSTROVSKII, O. V.; DUDCHENKO, G. P.; KOSOLAPOV, V. A.; KUCHERYAVENKO, A. F.; PARIONOV, N. P.; KOVALEV, S. G.; Khim. -Farm. Zh. 36 (2002) 12, 3-8; Nauchno-issled. inst. fiz. org. khim., Rostov. gos. univ., Rostov-na-Donu 344090, Russia; Russ.) -Mischke 21-115

Relationship between intraocular pressure lowering effect and chemical structure of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole derivatives

“…A total of 27 new compounds were synthesized as described previously [6] , [7] , [8] , [9] , [10] , [11] and tested for IOP lowering effect in ocular normotensive rats. These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole.…”

“…Benzimidazoles are heterocyclic compounds that are known for numerous therapeutic effects and are recognized as important pharmacophore in drug discovery [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] . Over the past years, several benzimidazole derivatives have been synthesized and their pharmacological activities investigated.…”

“…This data is supplementary to [1] presenting the effects of benzimidazole-based compounds on IOP of ocular normotensive rats. These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole [6] , [7] , [8] , [9] , [10] , [11] . In present article, data combine the results of pharmacophore and neural network analysis.…”

“…A total of 27 new compounds were synthesized as described previously and tested for IOP lowering effect in rats. These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . Experimental features All compounds were topically applied as a single drop, unilaterally, at 3 different concentrations (0.1%, 0.2% and 0.4%).…”

Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats

“… Data format Analyzed Experimental factors This data is supplementary to [1 , 2] . A total of 27 new compounds were synthesized as described previously [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] and tested for IOP lowering effect in rats. These compounds included twenty 9H-imidazo[1,2-a]benzimidazoles, four 10H-pyrimido[1,2-a]benzimidazoles, two 1H-pyrimido[1,2-a]benzimidazoles and one 1H-imidazo[1,2-a]benzimidazole.…”