Synthesis and Pharmacology of Some Pyrroles and Indan Amines: Hexahydro Indeno (1,2-c) Pyrroles and Indan Amines

Generation of Donor/Donor Copper Carbenes through Copper-Catalyzed Diyne Cyclization: Enantioselective and Divergent Synthesis of Chiral Polycyclic Pyrroles

“…> 50/1) in 77% yield, respectively. Of note, this tricyclic pyrrolidine motif can be found in a variety of bioactive molecules and may be of medicinal interest . Importantly, the enantioselectivity was well maintained in all these transformations.…”

Potential anticancer agents. Nitrogen mustards of aminophenylthiazoles

“…mg/kg per day).3 With R = CH2Ph, Ri = CH3, and R2 = OCH3, I had good activity against L 1210 lymphoid leukemia and Walker carcinosarcoma 256 (im). 3 The most active in this series (I) against L 1210 lymphoid leukemia (2 out of 6 cures at 25 mg/kg per day and T/C = 129% at 3 mg/kg per dav) had R = Ri = CH3andR2 = OCH3.…”

Palladium-Catalyzed [3 + 2] Annulation of ortho-Substituted Iodoarenes with Maleimides via a Consecutive Double Heck-type Strategy

“…For instance, maleimide motifs have been found in natural products, drugs, and active pharmaceutical intermediates. , In addition, succinimide-fused tricyclic frameworks encompass antihypertensive, hypertensive, anorexic, analgesic, anticonvulsant, and hyperglycemic activities (Figure ). − Due to their significant biological properties and pharmaceutical importance, some notable strategies have been established for attaining such heterocyclic frameworks; for instance, transition metal-catalyzed annulations effectively accomplish such heterotricyclic systems. − Despite the aforementioned notable strategies, there is still enough scope to develop efficient synthetic methodologies to accomplish such heterocyclic products. Mainly, maleimide and its derivatives are highly affordable and simple starting materials; therefore, in recent years, chemists have employed maleimides as leading coupling partners under induced catalytic transformations. − Especially, maleimide-based transition metal-catalyzed C–H activations to construct polycyclic molecules have been developed. − On the other hand, Pd-catalyzed activation of aryl halides and their eventual Heck couplings with olefins were found as one of the promising tools for constructing polycyclic molecules, − which can be extended to maleimides to get polycyclic compounds.…”