Synthesis and physico-chemical properties of poly(N-vinyl pyrrolidone)-based hydrogels with titania nanoparticles

Abstract

Poly(N-vinyl pyrrolidone) (PVP)-based hydrogels with titania nanoparticles (TN) were synthesized by the sol-gel method for the first time and were characterized in different states (native, freeze-dried, air-dried to constant weight and ground to powder, or swollen to constant weight in H 2 O or D 2 O) by various methods such as wide-angle and small-angle X-ray and neutron scattering, neutron spin-echo (NSE) spectroscopy, and scanning electron microscopy. The static (static polymer-polymer correlation length (mesh size), associates of crosslinks and PVP microchains) and dynamic (polymer chain relaxation rate, hydrodynamic polymer-polymer correlation length) structural elements were determined. The incorporation of titania nanoparticles into PVP hydrogel slightly increases the size of structural inhomogeneities (an increase in the static and dynamic polymer-polymer correlation length, the formation of associates of cross-links and PVP chains). Titania nanoparticles have an impact on the microstructure of the composite hydrogel and form associates with sizes from 0.5 to 2 lm attached to PVP hydrogel pore walls. The PVP and TN/PVP hydrogels show a high degree of water swelling. Moreover, the presence of titania nanoparticles in TN/PVP increases the number of water adsorption cycles compared to PVP hydrogel. The high swelling degree, bacteria-resistant and antimicrobial properties against Staphylococcus aureus allow considering NT/PVP hydrogels for medical applications as wound coatings.

More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing

“…Several characteristics, such as properties and applications, especially biomedical applications, of a hydrogel depend on the pore size of the inner structure, dispersion of NPs, and morphology [ 22 , 23 ]. For instance, the adsorption ability of a hydrogel is determined by the pore size, and the size of the drug determines whether the drug can be entrapped in the hydrogel network [ 24 , 25 ]. Scanning electron microscopy results indicated that the PEG-DA/PDA/PUE/FA hydrogel was highly interconnected and infiltrated throughout the pores.…”

Effect of graphene oxide on the pH‐responsive drug release from supramolecular hydrogels

“…The produced PPRs can precipitate through hydrogen bonding interactions between the external hydroxyl groups of the threaded α‐CD molecules 39 . Additionally, the diffractogram of PEG200/α‐CD64 shows a broad amorphous halo centered at 28° (d = 0.32 nm) corresponding to the short‐range local order of free water clusters occluded into the nanopores of the hydrogel, bound water (OH··· H  O  H ···OH linking via hydrogen bonds in PPR hydrogels) and half‐bound water (water molecules attached to hydrophilic zones in the PPR) 40 . This diffuse halo also has the contribution of the amorphous domains of PEG chains, which allow the retention of water into the PPR hydrogels 41 .…”

More Natural More Better: Triple Natural Anti-Oxidant Puerarin/Ferulic Acid/Polydopamine Incorporated Hydrogel for Wound Healing

“…Several characteristics, such as properties and applications, especially biomedical applications, of a hydrogel depend on the pore size of the inner structure, dispersion of NPs, and morphology [27][28] . For instance, the adsorption ability of a hydrogel is determined by the pore size, and the size of the drug determines whether the drug can be entrapped in the hydrogel network [29][30] . Scanning electron microscopy results indicated that the PEG-DA/PDA/PUE/FA hydrogel was highly interconnected and in ltrated throughout the pores.…”