Synthesis and rheological investigation of self-healable deferoxamine grafted alginate hydrogel

Xu, Guanzhe; Xiao, Yan; Cheng, Liang; Zhou, Runhua; Xu, Heng; Chai, Yimin; Lang, Meidong

doi:10.1002/polb.24334

Cited by 16 publications

(4 citation statements)

References 37 publications

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“…For all tested groups, it can be observed that G ′ and G ′′ are almost independent of the applied frequency from 0.1 to 2 Hz. Moreover, it was found that G ′ > G ′′ during all tested frequencies, which suggested a solidlike mechanical response. , At frequencies higher than 2 Hz, both G ′ and G ′′ increased, indicating a superior structural organization of the hydrogel network. ,− …”

Section: Resultsmentioning

confidence: 83%

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

Urzedo

Gonçalves

Nascimento

et al. 2020

ACS Biomater. Sci. Eng.

105

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Nitric oxide (NO) and silver nanoparticles (AgNPs) are well-known for their antibacterial activity. In this work, S-nitroso-mercaptosuccinic acid (S-nitroso-MSA), a NO donor, and green tea synthesized AgNPs were individually or simultaneously incorporated into alginate hydrogel for topical antibacterial applications. The obtained hydrogels were characterized and the NO release and diffusion of AgNPs and S-nitroso-MSA from alginate hydrogels were investigated. The hydrogels showed a concentration dependent toxicity toward Vero cells. The potent antibacterial effect of the hydrogels was demonstrated toward Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, and Streptococcus mutans UA159. Interestingly, the combination of S-nitroso-MSA and AgNPs into alginate hydrogels had a superior antibacterial effect, compared with hydrogels containing S-nitroso-MSA or AgNPs individually. This is the first report to describe the synthesis, cytotoxicity, and antibacterial effects of alginate hydrogel containing NO donor and AgNPs. These hydrogels might find important local applications in the combat of bacterial infections.

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Section: Resultsmentioning

confidence: 83%

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

Urzedo

Gonçalves

Nascimento

et al. 2020

ACS Biomater. Sci. Eng.

105

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“…3 b). The high mechanical properties of F-DFO-SA/BG hydrogel may be attributed by the newly formed hydrogen bond formation between DFO and SA [ 34 ]. The amine and carbonyl groups on the DFO could form hydrogen bond with the hydroxyl groups on the SA.…”

Section: Resultsmentioning

confidence: 99%

Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing

Zhang

Liu

et al. 2021

Bioactive Materials

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More and more studies have recognized that the nanosized pores of hydrogels are too small for cells to normally grow and newly formed tissue to infiltrate, which impedes tissue regeneration. Recently, hydrogels with macropores and/or controlled degradation attract more and more attention for solving this problem. Sodium alginate/Bioglass (SA/BG) hydrogel, which has been reported to be an injectable and bioactive hydrogel, is also limited to be used as tissue engineering scaffolds due to its nanosized pores. Therefore, in this study, degradation of SA/BG hydrogel was modulated by grafting deferoxamine (DFO) to SA. The functionalized grafted DFO-SA (G-DFO-SA) was used to form G-DFO-SA/BG injectable hydrogel. In vitro degradation experiments proved that, compared to SA/BG hydrogel, G-DFO-SA/BG hydrogel had a faster mass loss and structural disintegration. When the hydrogels were implanted subcutaneously, G-DFO-SA/BG hydrogel possessed a faster degradation and better tissue infiltration as compared to SA/BG hydrogel. In addition, in a rat full-thickness skin defect model, wound healing studies showed that, G-DFO-SA/BG hydrogel significantly accelerated wound healing process by inducing more blood vessels formation. Therefore, G-DFO-SA/BG hydrogel can promote tissue infiltration and stimulate angiogenesis formation, which suggesting a promising application potential in tissue regeneration.

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“…Hydrogen bonding has been used to achieve temperature responsiveness of self-healing hydrogels [ 73 ]. For example, the hydrogen bonding via freezing method has been used to develop the polyvinyl alcohol-based self-healing hydrogels [ 74 ].…”

Section: Self-healing Polymers In Medical Applicationmentioning

confidence: 99%

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

et al. 2021

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The versatility of polymeric materials as healing agents to prevent any structure failure and their ability to restore their initial mechanical properties has attracted interest from many researchers. Various applications of the self-healing polymeric materials are explored in this paper. The mechanism of self-healing, which includes the extrinsic and intrinsic approaches for each of the applications, is examined. The extrinsic mechanism involves the introduction of external healing agents such as microcapsules and vascular networks into the system. Meanwhile, the intrinsic mechanism refers to the inherent reversibility of the molecular interaction of the polymer matrix, which is triggered by the external stimuli. Both self-healing mechanisms have shown a significant impact on the cracked properties of the damaged sites. This paper also presents the different types of self-healing polymeric materials applied in various applications, which include electronics, coating, aerospace, medicals, and construction fields. It is expected that this review gives a significantly broader idea of self-healing polymeric materials and their healing mechanisms in various types of applications.

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Synthesis and rheological investigation of self-healable deferoxamine grafted alginate hydrogel

Cited by 16 publications

References 37 publications

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

Cytotoxicity and Antibacterial Activity of Alginate Hydrogel Containing Nitric Oxide Donor and Silver Nanoparticles for Topical Applications

Modulating degradation of sodium alginate/bioglass hydrogel for improving tissue infiltration and promoting wound healing

The Versatility of Polymeric Materials as Self-Healing Agents for Various Types of Applications: A Review

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