Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives

A selective androgen receptor modulator with minimal prostate hypertrophic activity restores lean body mass in aged orchidectomized male rats

“…JNJ-37654032 was identified as part of an extended program to discover nonsteroidal, orally bioavailable small molecules with anabolic effects on muscle and minimal androgenic effects on prostate [17][18][19]. It is one of the enantiomers of a benzimidazole analog reported previously ( Fig.…”

“…Our laboratory has identified several distinct chemical classes of nonsteroidal SARM [13][14][15][16][17][18][19][20][21][22][23]. These compounds were identified by screening in orchidectomized immature male rats.…”

A selective androgen receptor modulator with minimal prostate hypertrophic activity enhances lean body mass in male rats and stimulates sexual behavior in female rats

“…Our laboratory has identified several distinct chemical classes of nonsteroidal SARM [15][16][17][18][19][20][21][22][23][24][25]. These compounds were identified by screening in orchidectomized immature male rats.…”

Synthesis and In Vitro Urease Inhibition of Some Novel Benzimidazole‐based Hydrazones

“…Although all the positions of the benzimidazole ring can be substituted with a variety of chemical entities, most of the biologically active benzimidazole derivatives, obtained up to now, have functional groups at 1‐, 2‐, and/or 5‐ (or 6‐) positions . Literature survey reveals that 5,6‐dichlorobenzimidazole derivatives are very important for their pharmacological activities like antitumor, antioxidant, antiurease, antiparasitic, and antilipase (Scheme ) .…”