Synthesis and self-assembly of polyzwitterionic phenylboronic acid-containing double hydrophilic block copolymers

Marková, Pavlína; Uchman, Mariusz

doi:10.1016/j.eurpolymj.2021.110439

Cited by 7 publications

(2 citation statements)

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“…Such research could provide new insights important for applications such as quelation of metals by PEs in wastewater [ 14 , 15 , 16 , 17 ]. It could be also fundamental in the understanding of the ionization of weak PEs with groups capable to create strong intramolecular cross-links, which is the case of polyboronates [ 284 , 285 ]. With this aim, new theoretical and simulation methods need to be developed.…”

Section: Outlooksmentioning

confidence: 99%

Unusual Aspects of Charge Regulation in Flexible Weak Polyelectrolytes

et al. 2023

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This article reviews the state of the art of the studies on charge regulation (CR) effects in flexible weak polyelectrolytes (FWPE). The characteristic of FWPE is the strong coupling of ionization and conformational degrees of freedom. After introducing the necessary fundamental concepts, some unconventional aspects of the the physical chemistry of FWPE are discussed. These aspects are: (i) the extension of statistical mechanics techniques to include ionization equilibria and, in particular, the use of the recently proposed Site Binding-Rotational Isomeric State (SBRIS) model, which allows the calculation of ionization and conformational properties on the same foot; (ii) the recent progresses in the inclusion of proton equilibria in computer simulations; (iii) the possibility of mechanically induced CR in the stretching of FWPE; (iv) the non-trivial adsorption of FWPE on ionized surfaces with the same charge sign as the PE (the so-called “wrong side” of the isoelectric point); (v) the influence of macromolecular crowding on CR.

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Section: Outlooksmentioning

confidence: 99%

Unusual Aspects of Charge Regulation in Flexible Weak Polyelectrolytes

et al. 2023

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“…Under these conditions, they form stable esters with biomedically active vicinal diols, which can be released at a lower pH such as that found in tumor cells [ 41 , 42 , 43 , 44 , 45 ]. Thus, polymer-containing PBA molecules can be used not only as transporters for therapeutic agents but also as sensing molecules for various biomedical applications, due to their efficient encapsulation and release properties [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Triblock Terpolymer Conversion into Multi-Stimuli-Responsive Micelles with Dynamic Covalent Bonds for Drug Delivery through a Quick and Controllable Post-Polymerization Reaction

et al. 2023

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Stimuli-responsive copolymers are of great interest for targeted drug delivery. This study reports on a controllable post-polymerization quaternization with 2-bromomethyl-4-fluorophenylboronic acid of the poly(4-vinyl pyridine) (P4VP) block of a common poly(styrene)-b-poly(4-vinyl pyridine)-b-poly(ethylene oxide) (SVE) triblock terpolymer in order to achieve a selective responsivity to various diols. For this purpose, a reproducible method was established for P4VP block quaternization at a defined ratio, confirming the reaction yield by 11B, 1H NMR. Then, a reproducible self-assembly protocol is designed for preparing stable micelles from functionalized stimuli-responsive triblock terpolymers, which are characterized by light scattering and by cryogenic transmission electron microscopy. In addition, UV-Vis spectroscopy is used to monitor the boron-ester bonding and hydrolysis with alizarin as a model drug and to study encapsulation and release of this drug, induced by sensing with three geminal diols: fructose, galactose and ascorbic acid. The obtained results show that only the latter, with the vicinal diol group on sp2-hybridized carbons, was efficient for alizarin release. Therefore, the post-polymerization method for triblock terpolymer functionalization presented in this study allows for preparation of specific stimuli-responsive systems with a high potential for targeted drug delivery, especially for cancer treatment.

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