Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors

Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase

“…The inhibitory potential could be improved even further by replacing a substituted cycloalkyl or straight chain alkyl group for the cycloalkyl group. Compounds 218 and 220, as a result, might be viable novel therapeutic candidates for inhibiting the BChE enzyme 257 ( Table 9 ).…”