Synthesis and structure of Mn(II), Cu(II) and Zn(II) complexes containing bis-imidazole ligands

Abuskhuna, Suaad; McCann, Malachy; Briody, J. M.; Devereux, Michael; McKee, Vickie

doi:10.1016/j.poly.2004.04.015

Cited by 36 publications

(15 citation statements)

References 21 publications

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“…The largest distortion from regular square planar geometry is shown in the trans O-Cu-N angles [145.69(11)°and 140.36(11)°]. In similar structures the geometry around the metal centre was also considered as distorted square planar coordination with significant tetrahedral distortion [62][63][64][65][66][67][68]. Due to the coordination of the metal ion to the phenolic oxygen, reduced bond distances were observed for coordinated C-O [O1-C2 = 1.329(4) Å] compared to non-coordinated C-O [O4-C4 = 1.359(4) Å] bond lengths.…”

Section: Crystal Structure Of Copper(ii) Complexes 2a and 8amentioning

confidence: 99%

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Creaven

Duff

Egan

et al. 2010

Inorganica Chimica Acta

207

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a b s t r a c tThe condensation of substituted aromatic aldehydes with 7-amino-4-methyl-quinolin-2(1H)-one (1) has lead to the isolation of quinolin-2(1H)-one derived Schiff bases (2-14). The copper(II) complexes (2a-14a) of the ligands were also prepared, and together with their corresponding free ligands were fully characterised by elemental analyses, spectral methods (IR, 1 H and 13 C NMR, AAS, UV-Vis), magnetic and conductance measurements. The bidentate ligands coordinated to the copper(II) ion through the deprotonated phenolic oxygen and the azomethine nitrogen of the ligands in almost all cases. X-ray crystal structures of two of the complexes, 5a and 8a, confirmed the bidentate coordination mode. All of the compounds were investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to have excellent antiCandida activity but were inactive against Staphylococcus aureus and Escherichia coli. Selected compounds (2-8 and 2a-8a) were also screened for their in vitro anticancer potential using the human hepatic carcinoma cell line, Hep-G 2 . Several derivatives were shown to be active comparable to that of cisplatin.

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Section: Crystal Structure Of Copper(ii) Complexes 2a and 8amentioning

confidence: 99%

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Creaven

Duff

Egan

et al. 2010

Inorganica Chimica Acta

207

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“…X-ray crystallography was used to characterize these complexes. A single spacer tetrahedral carbon atom was present between two imidazole rings and formed stable six membered rings having N and NO with metals [16]. Two coordination polymers by using hydrothermal conditions were synthesized.…”

Section: Metal Complexes Of Nicotinic Acid and Imidazole:-cu +2 Complmentioning

confidence: 99%

“…, besides small functionalized derivatives, continued our structural-activity studies by exploring with the amino thiophenol area ('northeastern region') in your original target construction azalanstat (1). Inside vitro, most with the complexes in this series were found to be inhibitors that were highly potent with the stress-induced isozyme HO-1 and the constitutive isozyme HO-2, demonstrating only optimum selectivity with regard to HO-1.…”

Section: Mnmentioning

confidence: 99%

Cu AND Mn COMPLEXES OF NICOTINIC ACID AND IMIDAZOLE: A CURRENT REVIEW.

Khan¹,

Kanwal²,

Iqbal³

et al. 2017

IJAR

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“…Antihypertensive activity was observed in some N-hydroxyimidazole-5-methanamine derivatives [6], and N-hydroxyimidazole-3-oxides have been investigated as reactivators of organophosphateinhibited acetylcholinesterase enzymes [7]. Recently [8,9], we have described the synthesis and structures of a number of metal complexes containing bidentate, bis-imidazole ligands. A common structural feature of these ligands is that the two imidazole rings are linked by a single spacer tetrahedral carbon.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and structure of metal complexes containing zwitterionic N-hydroxyimidazole ligands

et al. 2007

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Cu(II) and Zn(II) complexes of N-hydroxyimidazoles were synthesised by reacting simple metal perchlorate salts with the imidazole ligand in alcohol and formulated with a metal:ligand ratio of 1:2. The X-ray crystal structures of five complexes (four Cu(II) and one Zn(II)) were obtained and each showed the two trans, N-hydroxyimidazole ligands forming six-membered, chelate rings with the metal. Both of the NO chelating, neutral N-hydroxyimidazole ligands are in the zwitterion form, with the uncoordinated imidazole imine N atom being protonated and the oxime O atom deprotonated. In the solid state the complexes form hydrogen-bonded supramolecular structures.

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Synthesis and structure of Mn(II), Cu(II) and Zn(II) complexes containing bis-imidazole ligands

Cited by 36 publications

References 21 publications

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Cu AND Mn COMPLEXES OF NICOTINIC ACID AND IMIDAZOLE: A CURRENT REVIEW.

Synthesis and structure of metal complexes containing zwitterionic N-hydroxyimidazole ligands

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