Five Ag(I) complexes containing the ligands bis(imidazol-2-yl)methane (2-BIM) and its derivatives were prepared and [Ag 2 (2-BIM) 2 ](ClO 4 ) 2 and [Ag 2 (2-BIM(Bz)OH) 2 ](ClO 4 ) 2 Á EtOH were characterised using X-ray crystallography. In each dimer the two Ag(I) ions are two-coordinate and there are small but definite argentophilic Ag-Ag (d 10 -d 10 ) interactions. All of the complexes display anti-fungal activity when tested in vitro against the fungal pathogen Candida albicans.

Synthesis and antimicrobial activity of (Z)-3-(1H-imidazol-1-yl)-2-phenylpropenenitrile and its metal complexes: X-ray crystal structures of the Zn(II) and Ag(I) complexes (3), respectively. Complexes 2 and 3 were characterised by X-ray crystallography. In 2 the metal lies in a pseudo-tetrahedral environment and is ligated by the imine nitrogens of two imppn ligands and an oxygen atom from each of two monodentate acetate anions. In the dimeric Ag(I) complex 3 each metal is coordinated to the imine nitrogens of two imppn ligands in an almost linear fashion and the two [Ag(imppn) 2 ] ' units are linked by an Ag Ã/Ag bond, supported by two trans bridging bidentate perchlorate groups and by p Á/p interactions between the ligands. In vitro tests on the ability of the compounds to inhibit the growth of the pathogenic yeast Candida albicans showed that imppn and its metal complexes were markedly less effective than the prescription drug, ketoconazole.

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Cu(II) and Zn(II) complexes of N-hydroxyimidazoles were synthesised by reacting simple metal perchlorate salts with the imidazole ligand in alcohol and formulated with a metal:ligand ratio of 1:2. The X-ray crystal structures of five complexes (four Cu(II) and one Zn(II)) were obtained and each showed the two trans, N-hydroxyimidazole ligands forming six-membered, chelate rings with the metal. Both of the NO chelating, neutral N-hydroxyimidazole ligands are in the zwitterion form, with the uncoordinated imidazole imine N atom being protonated and the oxime O atom deprotonated. In the solid state the complexes form hydrogen-bonded supramolecular structures.

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