Synthesis, structure and anti-fungal activity of dimeric Ag(I) complexes containing bis-imidazole ligands

Abstract

Five Ag(I) complexes containing the ligands bis(imidazol-2-yl)methane (2-BIM) and its derivatives were prepared and [Ag 2 (2-BIM) 2 ](ClO 4 ) 2 and [Ag 2 (2-BIM(Bz)OH) 2 ](ClO 4 ) 2 Á EtOH were characterised using X-ray crystallography. In each dimer the two Ag(I) ions are two-coordinate and there are small but definite argentophilic Ag-Ag (d 10 -d 10 ) interactions. All of the complexes display anti-fungal activity when tested in vitro against the fungal pathogen Candida albicans.

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