Synthesis and transformations of polyhedral compounds. Synthesis of 2-[quinolin-3(2)-yl]-1,3-diazaadamantanes

Arutyunyan, G. L.; Gevorkyan, K. A.; Arutyunyan, A. D.; Paronikyan, R. V.; Stepanyan, G. M.; Panosyan, G. A.

doi:10.1134/s1070428014100133

Cited by 4 publications

(2 citation statements)

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“…Later, the authors of [ 38 ] described the study of the activity of various quinolines ( 39 – 53 ) ( Fig. 5 ) against gram-positive ( S. aureus 209p) and gram-negative ( Sh.…”

Section: Biological Activity Of Azaadamantanesmentioning

confidence: 99%

“…The tested compounds (5 mg) were placed on Petri dishes and incubated with microorganisms. The diameter of the zones of no microorganism growth after incubation for 20–24 h was measured as described in works [ 37 , 38 ]. For the most active compounds, their minimum suppressive concentration (MIC) against S. aureus 209p and Sh.…”

Section: Biological Activity Of Azaadamantanesmentioning

confidence: 99%

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Azaadamantanes, a New Promising Scaffold for Medical Chemistry

et al. 2021

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Azaadamantanes are nitrogen-containing analogs of adamantane, which contain one or more nitrogen atoms instead of carbon atoms. This substitution leads to several specific chemical and physical properties. The azaadamantane derivatives have less lipophilicity compared to their adamantane analogs, which affects both their interaction with biological targets and bioavailability. The significant increase in the number of publications during the last decade (2009–2020) concerning the study of reactivity and biological activity of azaadamantanes and their derivatives indicates a great theoretical and practical interest in these compounds. Compounds with pronounced biological activity have been already discovered among azaadamantane derivatives. The review is devoted to the biological activity of azaadamantanes and their derivatives. It presents the main methods for the synthesis of di- and triazaadamantanes and summarizes the accumulated data on studying the biological activity of these compounds. The prospects for the use of azaadamantanes in medical chemistry and pharmacology are discussed.

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“…Later, the authors of [ 38 ] described the study of the activity of various quinolines ( 39 – 53 ) ( Fig. 5 ) against gram-positive ( S. aureus 209p) and gram-negative ( Sh.…”

Section: Biological Activity Of Azaadamantanesmentioning

confidence: 99%

Section: Biological Activity Of Azaadamantanesmentioning

confidence: 99%