Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of &lt;i&gt;N&lt;/i&gt;-(Alkyl/aralkyl)-&lt;i&gt;N&lt;/i&gt;-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

Abbasi, Muhammad Athar; Rehman, Azizur; Siddiqui, Sabahat Zahra; Sheeza, Anam; Nazir, Sumaira; Ahmad, Irshad; Malik, Rabia U.

doi:10.4274/tjps.84756

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The figures show that all the identified genes had the number of base pairs (bp) around 100, except rhIR gene where the number of base pairs was 120. Several previous results showed the ability of P. aeruginosa to form biofilm [23,24]. There are different factors that play an important role in its formation, QS phenomenon being one of them [25].…”

Section: Resultsmentioning

confidence: 98%

Detection of Quorum Sensing Genes of Pseudomonas aeruginosa Isolated from Different Areas in Iraq

Mohammed

Zgair

2022

Iraqi Journal of Science

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Pseudomonas aeruginosa is an opportunistic pathogen. Quorum sensing (QS) is one of processes that are responsible for biofilm formation. P. aeruginosa can live in different environments, some of which are pathogenic (clinical isolates) and some that are found outside the body (environmental isolates). The present study aimed to determine the presence of a number of genes responsible for QS in clinical and environmental isolates of P. aeruginosa. In the present study full DNA was separated from all environmental and clinical isolates that contained seven genes (rhlA, rhlR, rhlI, lasR, lasI, lasB, phzA1) associated with QS occurrence. The total DNA was separated from all environmental and clinical isolates (PAE1, PAE2, PAE3, PAE4, PAE5, PAE6, PAE7, PAE8, PAE10, PAE11, PAE12, PAE14, PAC1, PAC2, PAC5, PAC7, PAC8, PAC9 and PAC10). This study found that all studied environmental and clinical isolates contained the seven genes rhlA, rhlR, rhlI, lasR, lasI, lasB, phzA1, which was associated with QS occurrence.

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Section: Resultsmentioning

confidence: 98%

Detection of Quorum Sensing Genes of Pseudomonas aeruginosa Isolated from Different Areas in Iraq

Mohammed

Zgair

2022

Iraqi Journal of Science

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“…Inhibition of quorum sensing has the ability to inhibit virulence of bacteria and biofilms also (Afzal et al, 2021 ). Compounds having anti‐quorum‐sensing properties are able to control microbial infections, which is why researchers in the medical field are interested to explore more antimicrobial compounds (Abbasi et al, 2020 ). Phytobioactive compounds have remarkable antimicrobial properties (Shah et al, 2019 ).…”

Section: Bioassays For Phytobioactive Compoundsmentioning

confidence: 99%

Phytobioactive compounds as therapeutic agents for human diseases: A review

Riaz

Khalid

Afzal³

et al. 2023

Food Science & Nutrition

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Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: “Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc.” Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.

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Synthesis, characterization, photophysical and photochemical properties of peripherally tetra benzodioxane substituted metal-free phthalocyanine and its zinc(II) and magnesium(II) derivatives

Demirbaş

Ömeroğlu

Akçay

et al. 2021

Journal of Molecular Structure

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Synthesis, Antibacterial and Lipoxygenase Inhibition Studies of <i>N</i>-(Alkyl/aralkyl)-<i>N</i>-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-methylbenzenesulfonamides

Cited by 3 publications

References 23 publications

Detection of Quorum Sensing Genes of Pseudomonas aeruginosa Isolated from Different Areas in Iraq

Detection of Quorum Sensing Genes of Pseudomonas aeruginosa Isolated from Different Areas in Iraq

Phytobioactive compounds as therapeutic agents for human diseases: A review

Synthesis, characterization, photophysical and photochemical properties of peripherally tetra benzodioxane substituted metal-free phthalocyanine and its zinc(II) and magnesium(II) derivatives

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