Synthesis, antiproliferative activity and apoptosis-promoting effects of arene ruthenium(II) complexes with N, O chelating ligands

Mohan, Nanjan; Subarkhan, Mohamed Kasim Mohamed; Ramesh, Rengan

doi:10.1016/j.jorganchem.2018.01.022

Cited by 116 publications

(30 citation statements)

References 44 publications

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“…The synthesized complexes were characterized by various spectroscopic techniques such as FT-IR, 1 H NMR, 13 C NMR, ESI-Mass spectroscopy, UV-Vis, and Single-Crystal X-ray diffraction techniques. NMR spectra were recorded on a Bruker Advance II 400 MHz spectrometer using CDCl3 for 1 H NMR and CDCl3/DMSO (except complex 3 only CDCl3 was used) for 13 C NMR as solvents.…”

Section: -Benzoyl Pyridine 3-methoxy Benzhydrazide 4-hydroxy Benzhmentioning

confidence: 99%

“…Much attention has been paid to platinum group metal complexes because of their distinctive properties such as the ability to form stable complexes where π-ligated arene provides great stability to the metal centre thereby influencing their hydrophobicity and interaction with biomolecules [1]. Platinum group metals like ruthenium, rhodium and iridium have been reported to exhibit many properties like catalytic, photochemical and biological activities [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

et al. 2020

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Benzhydrazone half-sandwich platinum group metal complexes were prepared by the reaction of metal precursors and benzhydrazone derivative ligands which yielded chelating N∩O and N∩N bidentate cationic complexes. Ruthenium complexes formed N∩O while rhodium and iridium complexes formed N∩N bonding modes respectively. Antibacterial activity (against Grampositive and Gram-negative bacteria) as well as anti-cancer (HCT116 p53 +/+ and HCT116 p53-/-) studies for these complexes were carried out.

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Section: -Benzoyl Pyridine 3-methoxy Benzhydrazide 4-hydroxy Benzhmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

et al. 2020

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“…Apoptosis may be reckoned as an important obstacle for a damaged cell to become malignant tumors. Since the complexes promote apoptosis induction in cancer cells, flow cytometry using annexin V-FITC/propidium iodide (PI) double staining was carried out for the quantitative discrimination of apoptotic cells (Rehana et al., 2017 ; Mohan et al., 2018 ; Sathiya Kamatchi et al., 2020 ). Phosphatidylserine (PS) is a cell cycle signaling phospholipid located inner side of the membrane of a healthy cell but is reverted to the outer membrane for recognition by neighboring cells at the time of apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients

Xiao

Gao

et al. 2020

Drug Delivery

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Gastric cancer is a frequently occurring cancer with high mortality each year worldwide. Finding new and effective therapeutic strategy against human gastric cancer is still urgently required. Hence, we have established a new method to achieve treatment-actuated modifications in a tumor microenvironment by utilizing synergistic activity between two potential anticancer drugs. Dual drug delivery of gemcitabine (GEM) and Camptothecin-11 (CPT-11) exhibits a great anti-cancer potential, as GEM enhances the effect of CPT-11 treatment of human gastric cells by providing microenvironment stability. However, encapsulation of GEM and CPT-11 obsessed by poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) is incompetent owing to unsuitability between the binary free GEM and CPT-11 moieties and the polymeric system. Now, we display that CPT-11 can be prepared by hydrophobic covering of the drug centers with dioleoylphosphatidic acid (DOPA). The DOPA-covered CPT-11 can be co-encapsulated in PLGA NPs alongside GEM to stimulate excellent anticancer property. The occurrence of the CPT-11 suggestively enhanced the encapsulations of GEM into PLGA NPs (GEM-CPT-11 NPs). Formation of the nanocomposite (GEM-CPT-11 NPs) was confirmed by FTIR and X-ray spectroscopic techniques. Further, the morphology of GEM NPs, CPT-11 NPs, and GEM-CPT-11 NPs and NP size was examined by transmission electron microscopy (TEM), respectively. Furthermore, GEM-CPT-11 NPs induced significant apoptosis in human gastric NCI-N87 and SGC-791 cancer cells in vitro. The morphological observation and apoptosis were confirmed by the various biochemical assays (AO-EB, nuclear staining, and annexin V-FITC). In addition, evaluation of the hemolysis assay with erythrocytes of human shows excellent biocompatibility of free GEM, free CPT-11, GEM NPs, CPT-11 NPs, and GEM-CPT-11 NPs. The results suggest that GEM-CPT-11 NPs are one of the promising nursing cares for human gastric cancer therapeutic candidates worthy of further investigations.

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“…After 15 min, the samples were subjected to analysis by flow cytometry. The outcomes were analyzed with the BD FACS Calibur™ system (Mohan et al., 2018 ).…”

Section: Methodsmentioning

confidence: 99%

Precise engineering of Gemcitabine prodrug cocktails into single polymeric nanoparticles delivery for metastatic thyroid cancer cells

Liu

Han²,

Liu

et al. 2020

Drug Delivery

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GLOBOCAN estimates 36 types of cancers in 185 countries based on the incidence, mortality, and prevalence in the year 2019. Nowadays, chemotherapy is the most widely used cancer treatment among immune, radio, hormone, and gene therapies. Here, we describe a very simple yet cost-effective approach that synergistically combines drug reconstitution, supramolecular nano-assembly, and tumor-specific targeting to address the multiple challenges posed by the delivery of the chemotherapeutic Gemcitabine (GEM) drug. The GEM prodrugs were gifted to impulsively self-assemble into excellent steady nanoparticles size on covalent conjugation of linoleic acid hydrophobic through amide group with $100 nm. Newly synthesized GEM-NPs morphology was confirmed by various electron microscopic techniques. After successful synthesis, we have evaluated the anticancer property of GEM and GEM-NPs against B-CPAP (papillary thyroid carcinoma) and FTC-133 (human follicular thyroid carcinoma) cancer cell lines. Further studies such as AO-EB (acridine orange-ethidium bromide), nuclear staining and flow cytometry analyses on cell death mechanism signified that the cytotoxicity was associated with apoptosis in thyroid cancer cells. GEM-NPs show excellent biocompatibility compared to GEM. The present study explained that GEM-NPs as a safe and hopeful strategy for chemotherapeutics of thyroid cancer therapy and deserve for further clinical evaluations.

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Synthesis, antiproliferative activity and apoptosis-promoting effects of arene ruthenium(II) complexes with N, O chelating ligands

Cited by 116 publications

References 44 publications

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Synthesis, structural and in-vitro functional studies of half-sandwich platinum group metal complexes having various bonding modes of benzhydrazone derivative ligands

Combinational dual drug delivery system to enhance the care and treatment of gastric cancer patients

Precise engineering of Gemcitabine prodrug cocktails into single polymeric nanoparticles delivery for metastatic thyroid cancer cells

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