Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes

Abstract

N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide (NBTCS) was synthesized by condensation reaction of 4-chlorobenzenesulphonyl chloride and 2-aminobenzothiazole in acetone under reflux. Neodymium(III) and thallium(III) complexes of the ligand were also synthesized. Both ligand and metal complexes were characterized using UV-Vis, IR, 1H- and 13C-NMR spectroscopies, elemental analysis and molar conductance measurement. IR studies revealed that the ligand is tridentate and coordinates to the metal ions through nitrogen and oxygen atoms of the sulphonamide group and nitrogen atom attached to benzothiazole ring. The neodymium(III) complex displays a coordination number of eight while thallium(III) complex displays a coordination number of six. The ligand and its complexes were screened in vitro for their antibacterial activities against Escherichia coli strains (E. coli 6 and E. coli 13), Proteus species, Staphylococcus aureus and Pseudomonas aeruginosa using the agar well diffusion technique. The synthesized compounds were found to be more active against the microorganisms screened relative to ciprofloxacin, gentamicin and co-trimoxazole.

Synthesis, Biological and In Silico Studies of a Tripodal Schiff Base Derived from 2,4,6-Triamino-1,3,5-triazine and Its Trinuclear Dy(III), Er(III), and Gd(III) Salen Capped Complexes

“…Moreover, lanthanides have an interesting, but not well understood, biological role in living organisms as trace elements [ 34 ]. Our group recently reported neodymium(III) and thallium(III) complexes of N-benzothiazol-2-yl)-4-chlorobenzenesulphonamide as potential antibacterial agents [ 35 ]. Recently, Taha et al (2011) [ 36 ] reported that Nd, Dy, Sm, Pr, Gd, Tb, and Er complexes with bis-(salicylaldehyde)-1,3-propylenediimine Schiff base ligand possessed high antibacterial activity against Shigella dysenteriae , Pseudomonas aeruginosa , and Proteus vulgaris (Gram-negative bacteria).…”

Synthesis, characterization and cytotoxic activity of naturally isolated naringin-metal complexes

“…Metal complexes play an essential role in medicine and in agriculture (Agrawal, 2015). Metal complexes of Schiff bases possess anti-inflammatory, anti-allergic, antioxidant and analgesic, antifertility, enzymatic (Sing et al, 1999), antiproliferative (Ejidike and Ajibade, 2016) antiviral (Agrawal, 2015), and antimicrobial activity (Vasile Scăețeanu et al, 2018Vasile Scăețeanu et al, 2018, Obasi et al, 2017).…”

Synthesis, Characterization, Antimicrobial Screening, and Computational Studies of a Tripodal Schiff Base Containing Pyrimidine Unit

“…Gentamicin (C 21 H 43 N 5 O 7 ) belongs to the class of aminoglycosides and acts by preventing protein synthesis, thereby inhibiting the synthesis of nucleic acids (DNA replication or RNA synthesis) and causing death of the bacterium. Tetracycline (C 22 H 24 N 2 O 8 ) inhibits the multiplication of bacteria by binding to a subunit of the ribosomes, thereby inhibiting protein and nucleic acid synthesis and consequent death of the bacterium . Fluconazole is an antifungal drug (C 13 H 12 F 2 N 6 O) and belongs to synthetic triazoles.…”