Synthesis, characterization and antimicrobial activities of copper complexes derived from 4-aminoantipyrine derivatives

Joseph, J.; Nagashri, K.; Rani, G. Ayisha Bibin

doi:10.1016/j.jscs.2011.04.007

Cited by 67 publications

(38 citation statements)

References 18 publications

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“…The most spectacular advances in medicinal chemistry have been made when heterocyclic compounds played an important role in regulating biological activities. Heterocyclic moieties can be found in a large number of compounds that display biological activity . The increasing microbial resistance to antibiotics in use nowadays necessitates the search for new compounds with potential effects against pathogenic bacteria.…”

Section: Resultsmentioning

confidence: 99%

“…This increased lipophilicity enhances the permeation of the complexes into lipid membranes, blocking the metal binding sites in the enzymes of microorganisms. These complexes also disturb the respiration process of the cell and thus block the synthesis of the proteins that restrict further growth of the organism, and as a result the microorganisms die …”

Section: Resultsmentioning

confidence: 99%

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A facile synthesis of novel 5‐substituted pyridine 2 carboxamide derivatives and their biological evaluation and 3D QSAR studies

Dharman

Babu

Basha³

2018

J Chinese Chemical Soc

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A variety of novel 5‐substituted pyridine 2 carboxamides were designed and synthesized using both normal and solvent‐free microwave (MW) irradiation techniques. The results revealed that MW protocol proceeded smoothly under mild reaction conditions in short reaction times, thus avoiding the use of toxic organic solvents. Structural elucidation of the synthesized compounds was carried out on the basis of various spectroscopic methods, such as 1H NMR, 13C NMR, LCMS, and IR. The synthesized compounds were evaluated for their in vitro antimicrobial activity (MIC) using the agar disk diffusion method. Among the various synthetic compounds, compound 3b showed higher potential activity against Escherichia coli than the other compounds. The order of activity against E. coli of the studied compounds is 3b > 3e > 3g > 3h > 3d > 3c > 3a > 3f. Additionally, 2D and 3D structural features of the synthesized derivatives were recognized by the 3D‐QSAR model. This validated model exhibited good internal (r2, 0.924) and external prediction (r2pred, 0.851) correlation. The results of QSAR studies concluded that Alog P, the number of hydrogen bond acceptors, and the number of rotatable bonds were necessary features for the activity of the pyridine carboxamide derivatives.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A facile synthesis of novel 5‐substituted pyridine 2 carboxamide derivatives and their biological evaluation and 3D QSAR studies

Dharman

Babu

Basha³

2018

J Chinese Chemical Soc

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“…This value is higher than the spinonly value of 1.73 BM for one unpaired electron. The higher value of the magnetic moment indicates that complexes are monomeric in nature and there is no metal-metal interaction along the axial position in the complex and have distorted octahedral environment [35][36][37] . The magnetic moment of Co-PDCTC was found to lie in 2.05 BM.…”

Section: Resultsmentioning

confidence: 99%

Microwave Synthesis and Antimicrobial Activity of Some Copper (II), Cobalt (II), Nickel (II) and Chromium (III) Complexes with Schiff Base 2, 6-pyridinedicarboxaldehyde- Thiosemicarbazone

Ahmed¹,

Yunus²

2014

Orient. J. Chem

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“…The plates were allowed to stand for an hour in order to facilitate the diffusion of the drug solution. Then the plates were incubated at 37 °C for 24 h for bacteria and 48 h for fungus and the diameter of the inhibition zones was measured [17]. Minimum inhibition concentration is the lowest concentration (MIC) of solution to inhibit the growth of a test organism and MICs were detected by the serial dilution method.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

Vedanayaki¹,

Jayaseelan²

2016

Eur. J. Chem.

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New binucleating Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of the prepared ligands with N4 donor were synthesized. The ligands are obtained by the condensation of paraphenylenediamine with diacetylmonoxime and benzilmonoxime. The synthesized ligands and their metal complexes were characterized by elemental analysis and various spectroscopic techniques. The Cu(II), Ni(II) complexes were square planar, VO(II) complex was square pyramidal, whereas Mn(II), Zn(II) complexes were of tedrahedral geometry. Both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration method. The results showed that the metal complexes were found to be more active than free ligand. The DNA binding capacities of all the complexes were analyzed by using UV absorption spectra. The DNA cleaving capacities of all complexes were analyzed by agarose gel electrophoresis method against pBR322 DNA. KEYWORDS

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Synthesis, characterization and antimicrobial activities of copper complexes derived from 4-aminoantipyrine derivatives

Cited by 67 publications

References 18 publications

A facile synthesis of novel 5‐substituted pyridine 2 carboxamide derivatives and their biological evaluation and 3D QSAR studies

A facile synthesis of novel 5‐substituted pyridine 2 carboxamide derivatives and their biological evaluation and 3D QSAR studies

Microwave Synthesis and Antimicrobial Activity of Some Copper (II), Cobalt (II), Nickel (II) and Chromium (III) Complexes with Schiff Base 2, 6-pyridinedicarboxaldehyde- Thiosemicarbazone

Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

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