Synthesis, structural characterization and biological properties of Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of tetradentate Schiff bases

Abstract

New binucleating Cu(II), Ni(II), Mn(II), Zn(II) and VO(II) complexes of the prepared ligands with N4 donor were synthesized. The ligands are obtained by the condensation of paraphenylenediamine with diacetylmonoxime and benzilmonoxime. The synthesized ligands and their metal complexes were characterized by elemental analysis and various spectroscopic techniques. The Cu(II), Ni(II) complexes were square planar, VO(II) complex was square pyramidal, whereas Mn(II), Zn(II) complexes were of tedrahedral geometry. Both the ligands and their metal complexes were screened for their antibacterial and antifungal activities by minimum inhibitory concentration method. The results showed that the metal complexes were found to be more active than free ligand. The DNA binding capacities of all the complexes were analyzed by using UV absorption spectra. The DNA cleaving capacities of all complexes were analyzed by agarose gel electrophoresis method against pBR322 DNA. KEYWORDS

Synthesis,Characterization, biocidal, Anti-diabetic, Anti-inflammatory and Anti-Cancer(MCF-7) Studies of Schiff base ligand and its metal (II) complexes

“…Vibrational spectra of the compounds was recorded in Bruker Tensor 27 in the range of 4000-400 cm -1 . 1 H & 13 C NMR spectra were recorded on the Bruker 300 Hz spectrometer using DMSO-d 6 as a solvent. Mass spectrum was recorded for the L 1 , ML 1 & ML 1 L 2 using 410 Prostar Binary LC with 500MS IT PDA Detectors.…”

Theoretical Exploration of Enhanced Antioxidant Activity in Copper Complexes of Tetrahydroxystilbenes: Insights into Mechanisms and Molecular Interactions

“…These metal complexes can potentially exhibit enhanced antioxidant capabilities, such as flavonoid complexes that have demonstrated superior efficiency in radical inhibition. − To further enhance the antioxidant prowess of OXY, we propose its complexation with transition metals. A diverse array of geometries, coordination numbers, and oxidation states can be achieved. , The selection of the metal and the choice of mechanism play a significant role in boosting antioxidant capacity. , Experimental and theoretical studies have identified two well-distinct complexation mechanisms: direct chelation and coupled-deprotonation-chelation, with the latter being considered more plausible. , Copper complexes have attracted significant interest due to their remarkable anticancer and antioxidant properties, surpassing those of nickel, cobalt, and zinc complexes. − Encouraging outcomes from joint experimental and theoretical studies on copper-resveratrol complexes , have motivated us to explore the complexation of OXY with copper in its two oxidation states, Cu + and Cu 2+ . To the best of our knowledge, complexes of Cu + and Cu 2+ with the ligand Resveratrol substituted by OH in position (5′) have not been determined experimentally.…”

Synthesis, Spectroscopic and Biological Activities Of Complexes Of 2-[(3-Chlorobenzylidene) Hydrazinylidene]-1,2-Diphenylethanimine

“…Beyond its applications in organic synthesis, α-benzilmonoxime has found utility in research endeavors aimed at exploring reaction mechanisms, kinetics, and other facets of organic chemistry [4][5][6]. Furthermore, investigations into certain compounds related to α-benzilmonoxime have been conducted to assess their potential biological activity [7][8][9]. However, obtaining specific details on this aspect may necessitate consulting the most recent scientific literature.…”