Synthesis, characterization and application of chitosan-N-(4-hydroxyphenyl)-methacrylamide derivative as a drug and gene carrier

Jaiswal, Shefali; Dutta, Pradip Kumar; Kumar, Santosh; Koh, Joonseok; Lee, Myung Chul; Lim, Jae Woon; Pandey, Shambhavi; Garg, Pankaj

doi:10.1016/j.ijbiomac.2021.11.204

Cited by 13 publications

(2 citation statements)

References 77 publications

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“…Chitosan possesses various highly desirable features, which include biocompatibility and versatility as far as formulation techniques are concerned. These characteristics make chitosan a highly sought after biomaterial with technological applications in cosmetics [ 40 , 41 ], pharmaceutical [ 42 , 43 ], and biomedical [ 44 , 45 ] industries. However, despite all this, as this review will highlight, there is a deficiency of usage of chitosan in the formulation of nanoparticulate technologies that can be used for, and are being used for, atherosclerosis research (diagnostics, therapeutics, and theranostics).…”

Section: Chitosan—a Promising Biopolymer That Has Potential In Athero...mentioning

confidence: 99%

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Sriamornsak

Dass

2022

Pharmaceutics

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Chitosan is a natural biopolymer that is present in an abundant supply in sources such as crustacean shells, mushrooms, and insect exoskeletons. It can be used to make a variety of types of drug formulations and is generally safe to use in vivo; plus, it has inherent cholesterol-reducing properties. While an abundance of papers has tested this biopolymer in nanoparticles in cancer and diabetes research, there is a lag of usage, and hence the paucity of information, in the area of cardiovascular research, specifically in atherosclerosis, the topic of this review. This review highlights some of the deficiencies in this niche area of research, examines the range of chitosan nanoparticles that have been researched to date, and proposes several ways forward to advance this field. Nanoparticles used for both diagnostic and therapeutic purposes are reviewed, with a discussion on how these nanoparticles could be better researched in future and what lays ahead as the field potentially moves towards clinical trials in future.

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Section: Chitosan—a Promising Biopolymer That Has Potential In Athero...mentioning

confidence: 99%

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Sriamornsak

Dass

2022

Pharmaceutics

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“…The amino and hydroxy groups contained in the structure of chitosan make it hydrophilic [9] and limit its use as a petroleum and oil sorbent. However, this structural feature allows chemical modification of chitosan and materials based on it to control the lyophilic properties by performing reactions that are specific to the listed functional groups: N, O-alkylation [10], acylation [11,12], sulfatation [13], phosphorylation [14], quaternization [15], graft copolymerization, and others [16][17][18][19]. In particular, chitosan modification can be performed in solution before the material-forming stage.…”

Section: Introductionmentioning

confidence: 99%

Lyophilic and Sorption Properties of Chitosan Aerogels Modified with Copolymers Based on Glycidyl Methacrylate and Alkyl Methacrylates

et al. 2022

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This paper discusses the influence of the structure of copolymers based on glycidyl methacrylate and alkyl methacrylates with C6–C18 hydrocarbon side groups on the wettability and sorption properties of surface-modified chitosan aerogels. The grafting of copolymers onto the surface of aerogels was confirmed by elemental analysis, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy. As a result of the modification, with an increase in the amount of the hydrocarbon substituent alkyl methacrylate, the surface of the resulting materials became hydrophobic with contact angles in the range of 146–157°. At the same time, the water absorption of the aerogels decreased by a factor of 30 compared to that for unmodified aerogels, while the sorption capacity for light oil, diesel fuel, and synthetic motor oil remained at the level of more than 30 g/g. Chitosan aerogels with grafted copolymers based on glycidyl methacrylate and alkyl methacrylates retain biodegradation capacity; however, compared to unmodified chitosan, this process has an induction period.

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'Click' synthesized non-substituted triazole modified chitosan from CaC2 as a novel antibacterial and antioxidant polymer

Chawla

Dutta

2022

J Polym Res

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Synthesis, characterization and application of chitosan-N-(4-hydroxyphenyl)-methacrylamide derivative as a drug and gene carrier

Cited by 13 publications

References 77 publications

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

Lyophilic and Sorption Properties of Chitosan Aerogels Modified with Copolymers Based on Glycidyl Methacrylate and Alkyl Methacrylates

'Click' synthesized non-substituted triazole modified chitosan from CaC2 as a novel antibacterial and antioxidant polymer

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