Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol

Antimicrobial, hemolytic and thrombolytic activities of some new N-substituted-2-({5-[(1E,3E)F-4-(1,3-benzodioxol- 5-yl)-1,3-butadienyl]-1,3,4-oxadiazol-2-yl}sulfanyl) propanamides

“…Piperic carbohydrazide (4; 0.04 mol) was mixed in 150 mL of ethanol with solid KOH (0.04 mol) in a 250-mL round-bottom flask and the mixture refluxed. Carbon disulfide (0.08 mol) was added dropwise and the mixture refluxed for 6 h. Excess distilled water (100 mL) was added and the pH was adjusted to 5 -6 with dilute HCl [12]. The title compound was collected by filtration and dried.…”

“…The mixture was further stirred for 45 min with lithium hydride (0.001 mol) at room temperature. The synthesized electrophiles, 2-bromo-N-(alkyl/aralkyl/aryl) propanamides (8a-o), were added and the mixture again stirred for 4 -5 h. Excess cold distilled water was poured into the mixture, which was then allowed to stand for 1 h. The Ssubstituted derivatives of 5 were obtained as solid precipitates [13].…”

Synthesis of N'-Substituted-2-(5-(4-Chlorophenyl)-1,3,4- oxadiazol-2-ylthio)acetohydrazide Derivatives as Suitable Antibacterial Agents

“…The antibacterial activity assay was executed as reported in the literature [10,11]. Antibacterial activity was performed in sterile 96-wells microplates under aseptic conditions.…”

“…The 2,5-substituted-1,3,4-oxadiazole derivatives, which have often been synthesized in the last decade, exhibit a number of biological activities [3][4][5][6][7] . In continuation of a previous synthetic work using 1,3,4-oxadiazole derivatives [8,9], N-substituted derivatives of 2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazide have been synthesized in this study to determine their antibacterial potential.…”

Synthesis, Multiparametric Structure Assessment and Biological Evaluation of Some New 1,3,4-Oxadiazoles Containing Piperidine Nucleus

“…In continuation to our previous work on oxadiazole derivatives having azinane core [15] by the cost effective methods for the synthesis of biologically important compounds, 1,3,4-oxadiazole derivatives bearing piperidine nucleus have been synthesized to combat the vastly resistive pathogens for already available drugs.…”