Synthesis, characterization and cytotoxicity investigation of juglone palladium complex; theoretical and biological properties of juglone as an employed ligand

Mehdipour, Ebrahim; Hasanvandi, Siavash; Shafieyoon, Parvaneh

doi:10.1007/s13738-022-02532-9

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Drug treatment was initiated after a 4-hour incubation period. Stock solutions (20 µg/mL in DMSO) of [Fe(poly(AHAEBD)2].Na3 and poly(AHAEBD), and cisplatin (40 µg/mL in deionized water) were prepared and subsequently diluted with the culture medium to achieve the desired concentrations whenever needed [23][24][25].…”

Section: Cell Culturementioning

confidence: 99%

Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line

Neisi,

Hasanvandi

2023

Preprint

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In the present study, linear novel polymer poly(1-(2-((3-amino-2-hydroxypropyl)amino)ethyl)-1'-ethyl-[4,4'-bipyridine]-1,1'-di-ium) (poly(AHAEBD)) and its complex with iron (ΙΙΙ) ([Fe(poly(AHAEBD)2].Na3) were synthesized and then their anticancer effects on A375 human malignant melanoma cells line were evaluated. The structure of the synthesized compounds was confirmed using Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1HNMR), field emission scanning electron microscopy (FE-SEM), X-ray energy diffraction analysis (EDS) and gel permeation chromatography (GPC). Also, the cytotoxicity of cisplatin as a reference, on A375 melanoma cell line was tested. The IC50 of polymer-complex [Fe(poly(AHAEBD)2].Na3 (0.71 µg/mL), cisplatin (4.58 µg/mL) and poly(AHAEBD) (1.73 µg/mL) were obtained. Our results revealed that the polymer-complex [Fe(poly(AHAEBD)2].Na3 exhibited better performance compared to cisplatin. Furthermore, the coordination with iron (III) enhanced the cytotoxicity levels of poly(AHAEBD). According to these findings, the synthesized polymer-complex demonstrates remarkable potential as an anti-cancer agent. This study could provide the basis for future research focused on employing this new polymer-complex for in vivo testing, highlighting its potential for therapeutic applications.

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Section: Cell Culturementioning

confidence: 99%

Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line

Neisi,

Hasanvandi

2023

Preprint

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“…In other words, the palladium complex has anticancer properties [17,18]. It has been accepted that changing the structural parts of the sulfonamide, and synthesis pd complex as the new drug has been designed in recent investigations [19][20][21][22]. These results prompted us to synthesize and evaluate a new series of sulfonamide derivatives for medicinal and pharmaceutical chemistry.…”

Section: Introductionmentioning

confidence: 99%

"Synthesis, and Biological Investigation of Bis [N-(4-Pyridyl) Sulfonamide] Dichloride Palladium: MEP, and Molecular Docking as an Antibacterial and an Anticancer Agents"

Shafieyoon¹

2023

BJSTR

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In the present work, the compound (N-(4-pyridyl-p-toluene sulfonamide) as a ligand was prepared from the reaction of 4-aminopyridine and p-toluene sulfonyl chloride in presence of one molar potassium hydroxide solution as a base and tetrahydrofuran as a solvent. Palladium dichloride was used for the synthesis of [bis (N-(4-pyridyl-p-toluene sulfonamide)] complex. The structure of the synthesized compounds was confirmed by FTIR. Elemental analysis of palladium by Inductively Coupled Plasma (ICP) and hot loading filtration test. MEP (Molecular Electrostatic Potential) of ligand and molecular docking ligand and pd complex was performed. This research indicated ligand of sulfonamide was Biocompatible and has an antibacterial property and its pd complex is an anticancer agent.

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Synthesis, characterization and cytotoxicity investigation of juglone palladium complex; theoretical and biological properties of juglone as an employed ligand

Cited by 2 publications

References 44 publications

Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line

Synthesis of a Novel Polymer- Iron (ΙΙΙ) Complex and Study of Its Anticancer Properties on A375 Melanoma Cell Line

"Synthesis, and Biological Investigation of Bis [N-(4-Pyridyl) Sulfonamide] Dichloride Palladium: MEP, and Molecular Docking as an Antibacterial and an Anticancer Agents"

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