Synthesis, characterization, and cytotoxicity of the plasmid EGFP-p53 loaded on pullulan–spermine magnetic nanoparticles

Eslaminejad, Touba; Nematollahi-Mahani, Seyed Noureddin; Ansari, Mehdi

doi:10.1016/j.jmmm.2015.11.037

Cited by 31 publications

(10 citation statements)

References 38 publications

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“…The decrease of saturation magnetizations after modification and combination could be contributed to the existence of non-magnetic materials. 33 These features of TMGO made the highly efficient magnetic separation available with ordinary external magnetic field. …”

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confidence: 99%

Preparation of Tetraethylenepentamine Modified Magnetic Graphene Oxide for Adsorption of Dyes from Aqueous Solution

Tang¹,

Tang²,

Liu³

2017

J. Braz. Chem. Soc.

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In this study, tetraethylenepentamine modified magnetic graphene oxide nanomaterial (TMGO) was prepared and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS) and vibration sample magnetometer (VSM). All the characterizations proved that the modification and preparation of TMGO were successful. The TMGO nanomaterial was used in the adsorption of Acid Red 18 (AR) in aqueous solution. The parameters like pH of solution, adsorption kinetics and isotherms were all investigated. The results indicated that the TMGO nanomaterial had satisfied adsorption ability and the maximum adsorption capacity was 524.2 mg g -1 at 45 °C and pH 6. The adsorption capacity remained at 91.8% of the initial value after five cycles. The adsorption process with AR was found through fitting the pseudo-second-order kinetics equations and the Freundlich adsorption model. The experimental results demonstrated that the TMGO nanomaterial could be rapidly extracted from the medium and had a good adsorption ability to remove dyes in wastewater.Keywords: adsorption, dye, graphene oxide, magnetic nanoparticles, tetraethylenepentamine IntroductionIncreasing interests were focused on the environmental health, especially the removal of toxic organic or inorganic pollutants from water because of the water pollution during the development of modern industry.1 Among the various toxic pollutants, dye was one of the most serious problems because of the visible color, complex component and low biodegradability.2 Dye was widely used in direct textiles, printing and dyeing. It showed many damages to plants, animals and human beings.3 Therefore, wastewater containing dyes should be treated adequately before being discharged. 4 The development of materials for removal of dyes exhibited considerable importance.Recently, many kinds of materials and nanomaterials such as silica nanoparticles, carbon nanotube, gold nanoparticles and metal oxide nanoparticles were utilized as adsorbents for removal of toxic compounds. [5][6][7][8] Graphene oxide (GO) attracted significant interests due to its high mechanical strength and facile functionalization ability.9 It could be a good material for adsorption owing to the large specific surface area, abundant oxygen containing groups and high water solubility.10-12 Magnetic nanoparticles (MN) were also good in separation of toxic dyes by simply using an ordinary magnet. 13,14 After the combination of MN and GO, magnetic GO (MGO) and related complex nanomaterials were prepared and used in pollution control and sensors were benefited from the advantages of both During the various kinds of applications, many advantages of MGO were demonstrated including high adsorption capacity, easy recycling and improved stability.In this study, tetraethylenepentamine was used in the modification of Fe 3 O 4 magnetic nanoparticle (TMN) Tang et al. 335 Vol. 29, No. 2, 2018 to increase amino group...

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confidence: 99%

Preparation of Tetraethylenepentamine Modified Magnetic Graphene Oxide for Adsorption of Dyes from Aqueous Solution

Tang¹,

Tang²,

Liu³

2017

J. Braz. Chem. Soc.

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“…20 Therefore, polymeric, particulate, macromolecular and cellular carriers have been developed as diverse types of drug delivery vectors. [44][45][46] Microspheres, nanoparticles, micelles and liposomes are all among colloidal forms of DDS. 47 Microemulsions have become popular as new DDS that are composed of at least water, oil and surfactants.…”

Section: Discussionmentioning

confidence: 99%

<p>Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review</p>

Ohadi¹,

Shahravan²,

Dehghannoudeh³

et al. 2020

DDDT

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Background: Microemulsions drug delivery systems (MDDS) have been known to increase the bioavailability of hydrophobic drugs. The main challenge of the MDDS is the development of an effective and safe system for drug carriage and delivery. Biosurfactants are preferred surface-active molecules because of their lower toxicity and safe characteristics when compared to synthetic surfactants. Glycolipid and lipopeptide are the most common biosurfactants that were tested for MDDS. The main goal of the present systematic review was to estimate the available evidence on the role of biosurfactant in the development of MDDS. Search Strategy: Literature searches involved the main scientific databases and were focused on the period from 2005 until 2017. The Search filter composed of two items: "Biosurfactant" and/or "Microemulsion." Inclusion Criteria: Twenty-four studies evaluating the use of biosurfactant in MDDS were eligible for inclusion. Among these 14 were related to the use of glycolipid biosurfactants in the MDDS formulations, while four reported using lipopeptide biosurfactants and six other related review articles. Results: According to the output study parameters, biosurfactants acted as active stabilizers, hydrophilic or hydrophobic linkers and safety carriers in MDDS, and among them glycolipid biosurfactants had the most application in MDDS formulations. Conclusion: Synthetic surfactants could be replaced by biosurfactants as an effective biosource for MDDS due to their excellent self-assembling and emulsifying activity properties.

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“…as therapeutic agents, there are several pieces of evidence of the preclinical efficiency of these nanosystems in gene therapy (31)(32)(33)(34). Companies have a commercial interest in the production of nanoparticles, because of their easy large-scale production.…”

Section: Nanoparticles For Pdna Transfectionmentioning

confidence: 99%

Nanoparticles for death‑induced gene therapy in cancer (Review)

et al. 2017

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Due to the high toxicity and side effects of the use of traditional chemotherapy in cancer, scientists are working on the development of alternative therapeutic technologies. An example of this is the use of death‑induced gene therapy. This therapy consists of the killing of tumor cells via transfection with plasmid DNA (pDNA) that contains a gene which produces a protein that results in the apoptosis of cancerous cells. The cell death is caused by the direct activation of apoptosis (apoptosis‑induced gene therapy) or by the protein toxic effects (toxin‑induced gene therapy). The introduction of pDNA into the tumor cells has been a challenge for the development of this therapy. The most recent implementation of gene vectors is the use of polymeric or inorganic nanoparticles, which have biological and physicochemical properties (shape, size, surface charge, water interaction and biodegradation rate) that allow them to carry the pDNA into the tumor cell. Furthermore, nanoparticles may be functionalized with specific molecules for the recognition of molecular markers on the surface of tumor cells. The binding between the nanoparticle and the tumor cell induces specific endocytosis, avoiding toxicity in healthy cells. Currently, there are no clinical protocols approved for the use of nanoparticles in death‑induced gene therapy. There are still various challenges in the design of the perfect transfection vector, however nanoparticles have been demonstrated to be a suitable candidate. This review describes the role of nanoparticles used for pDNA transfection and key aspects for their use in death‑induced gene therapy.

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Synthesis, characterization, and cytotoxicity of the plasmid EGFP-p53 loaded on pullulan–spermine magnetic nanoparticles

Cited by 31 publications

References 38 publications

Preparation of Tetraethylenepentamine Modified Magnetic Graphene Oxide for Adsorption of Dyes from Aqueous Solution

Preparation of Tetraethylenepentamine Modified Magnetic Graphene Oxide for Adsorption of Dyes from Aqueous Solution

<p>Potential Use of Microbial Surfactant in Microemulsion Drug Delivery System: A Systematic Review</p>

Nanoparticles for death‑induced gene therapy in cancer (Review)

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