Synthesis, characterization, and in-vitro evaluation of piperine-loaded silica/hydroxyapatite mesoporous nanoparticles

Gorgani, Leila; Mohammadi, Maedeh; Darzi, Ghasem Najafpour; Nikzad, Maryam; Kazemi, Sohrab

doi:10.1007/s11696-021-01813-6

Cited by 3 publications

(1 citation statement)

References 53 publications

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“…The main challenge in developing piperine-based formulations for therapeutic usage is their limited water solubility due to their hydrophobic nature, which lowers their bioavailability. 4 Certain drawbacks were reported from traditional dosage forms such as poor solubility and permeability, poor bioavailability, degradation by gastrointestinal enzyme, food interactions, and toxicity. Novel lipid-based nanoformulation has received considerable interest in drug delivery methods to circumvent these limitations.…”

Section: Introductionmentioning

confidence: 99%

UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool

Kalgonda Patil,

Jalalpure,

Chimagave

et al. 2023

Ind. J. Pharm. Edu. Res

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Aim:The current study aims to establish and validate a UV-spectrophotometric approach for estimating piperine in black pepper, commercial Ayurvedic preparation, and novel piperine-loaded nanoformulation. Materials and Methods: The UV-spectrophotometric technique was developed using methanol as a solvent. Piperine showed the absorbance at 342 nm. In accordance with ICH Q2 (R1) guidelines, the developed method was extensively validated in terms of selectivity, linear range, precision, accuracy, robustness, ruggedness, and reproducibility. The new method was also effectively used for precise estimation of piperine in black pepper, commercial Ayurvedic preparation and novel piperine loaded nanoformulation. The stability indicating study of the established UV-spectroscopic approach was carried as per as per ICH Q1A (R 2 ) guidelines. Results: The optimal parameters for piperine analysis were established using methanol as solvent. With the line equation y = 0.067x + 0.005, the maximum absorption wavelength was found to be 342 nm. Between concentration ranges of 0.5-32µg/ mL, it showed a linear response. The linear regression coefficient was found to be 0.999. The method's linearity, accuracy, ruggedness, specificity, and sensitivity were all validated, and all validation results were confirmed to be in acceptable ranges. Piperine was found to be stable and less prone to degradation under acidic, basic, thermal and photolytic stress conditions whereas oxidation degradation showed extremely degradable characteristics. Conclusion: The established approach will serve as standard quality control tool for precise estimation of piperine in herbal formulations and can be used for quality analysis.

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Section: Introductionmentioning

confidence: 99%

UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool

Kalgonda Patil,

Jalalpure,

Chimagave

et al. 2023

Ind. J. Pharm. Edu. Res

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Recent trends on biomaterials for tissue regeneration applications: review

Farag

2023

J Mater Sci

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Tissue engineering is approach of replacing or regeneration of biological functions of tissues or organs by using combination of biomaterials, biomolecules and cells. Tissue engineering mainly depends scaffold biomaterials and scaffold fabrication methods. Therefore, there have been progressive investigation and development of new biomaterials with different formulations to help and achieve necessary requirements in the tissue engineering applications. This review is briefly representing necessary features associated with biomaterial type and design required for tissue regeneration applications, and presenting earlier research in tissue engineering field and new trends for future implementation. It is mainly focusing on generations of biomaterials and discovery tissue engineering field. As well as, different types of biomaterials, such as bioceramics, bioactive glasses, synthetic and natural polymers and their derived composites, used in fabrication of scaffolds (as a main part of tissue engineering) are demonstrated in this review. Scaffold fabrication methods are also reviewed here. Moreover, it is showing the recent achievements in tissue engineering field for bone, skin, cartilage, neural, and cardiac regeneration as a pre-clinical procedure for repair of injured and diseased tissues and organs. Finally, recent trends and challenges of biomaterials for tissue regeneration are presented also in this review. Graphical abstract

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Lignin nanoparticles as a promising nanomaterial for encapsulation of Rose damascene essential oil: Physicochemical, structural, antimicrobial and in-vitro release properties

Khodadadi,

Nikzad,

Hamedi

2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Synthesis, characterization, and in-vitro evaluation of piperine-loaded silica/hydroxyapatite mesoporous nanoparticles

Cited by 3 publications

References 53 publications

UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool

UV-spectrophotometric Method Development and Validation for Piperine Estimation in Black Pepper, Ayurvedic Formulation and Novel Nano Formulation: A Perfect Quality Assessment Tool

Recent trends on biomaterials for tissue regeneration applications: review

Lignin nanoparticles as a promising nanomaterial for encapsulation of Rose damascene essential oil: Physicochemical, structural, antimicrobial and in-vitro release properties

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