Synthesis  , Characterization and Study Biological Activity Some New Derivatives  Amide and Pyrazole –Pyrazoline of Steroid Analogs .

A.A.AL-Rida, Nabeel; Farhan, Ali M.

doi:10.29350/jops.2019.24.3.971

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New bi aryl amide derivatives of steroid analoge via Suzuki reaction synthesis and characterization

Farhan,

Abdul-Rida

2023

2nd International Conference of Mathematics, Applied Sciences, Information and Communication Technology

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New bi aryl amide derivatives of steroid analoge via Suzuki reaction synthesis and characterization

Farhan,

Abdul-Rida

2023

2nd International Conference of Mathematics, Applied Sciences, Information and Communication Technology

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Preparation and Characterization Biaryl aromatic compounds of the pyrimidine derivative by a Suzuki Coupling reaction and study their anti-cancer effect

Abdul-Rida

Gareeb

2020

J. Phys.: Conf. Ser.

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This study includes the synthesis and characterization of some heterocyclic compounds (pyrimidine derivatives) starting from the reaction of 2-Bromo benzaldehyde with the amino compound in an acidic medium to obtain a base derivative of Schiff Base (1) and then (1) interacts with aromatic boronic acids (3-Carboxyx-5-nitro, 3-Cyano, 4-Ethoxy, 2,3-Difluoro, 2,3,4-Trifluoro, 4-Chloro) respectively by reaction Suzuki-Mayura and with the presence of Tetrax (Triphenyl Phosphine) Palladium (0) and a basic medium to give new derivatives of Diphenyl (2-7). The derivatives that were manufactured were Characterization through the FT-IR spectroscopy, proton magnetic resonance spectrum 1H-NMR, and carbon carbon resonance spectrum 13C-NMR. In addition to the elemental analysis C.H.N, the cytotoxicity of the derivatives (2-4) was examined in the laboratory on a MCF-7 and SK-LU-1 using the MTT assay, and it was found that the derivative (2) had very good efficacy at a certain concentration.

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Synthesis of steroid bearing heterocyclic derivatives and biological activity. Review 2014-2020

Farhan¹,

Alshamusi

Jebur³

2021

J. Phys.: Conf. Ser.

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Steroidal building blocks have drawn research groups attention in many branches of science and technology, such as pharmacological and medical fields, supramolecular chemistry and compounds in nanotechnology, So the recent years have witnessed a wide focus of research directed towards preparing heterocyclic derivatives fused with steroid molecules as a result of the great biological activity these compounds, This review described an outline of the literature reports (2014-2020) of synthesis heterocyclic compounds for steroid molecules fused at rings-A or B or D of steroid skeleton or annealed, Also the review included the biological activity of steroid hetero cyclic as anti breast cancer, anti prostate cancer, antioxidant and antimicrobial.

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Synthesis , Characterization and Study Biological Activity Some New Derivatives Amide and Pyrazole –Pyrazoline of Steroid Analogs .

Cited by 3 publications

References 0 publications

New bi aryl amide derivatives of steroid analoge via Suzuki reaction synthesis and characterization

New bi aryl amide derivatives of steroid analoge via Suzuki reaction synthesis and characterization

Preparation and Characterization Biaryl aromatic compounds of the pyrimidine derivative by a Suzuki Coupling reaction and study their anti-cancer effect

Synthesis of steroid bearing heterocyclic derivatives and biological activity. Review 2014-2020

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